急性胰腺炎乌司他丁治疗临床疗效研究.docVIP

急性胰腺炎乌司他丁治疗临床疗效研究 　　摘要：目的：分析急性胰腺炎乌司他丁治疗的临床疗效。方法：选取本院收治的60例急性胰腺炎临床资料，随机分为治疗组与对照组，各30例。对照组采取常规治疗，治疗组实施乌司他丁治疗，对比两组患者临床疗效。结果：治疗组总有效率为93.33%明显高于对照组的76.67%，差异有统计学意义（Plt;0.05）。治疗组腹痛缓解时间、胰腺水肿消失时间、首次主动排便时间均明显短于对照组，差异有统计学意义（Plt;0.05）。治疗组治疗后CRP、TNF-a、IL-15、IL-10等水平明显低于对照组，差异有统计学意义（Plt;0.05）。治疗组不良反应发生率为6.67%明显低于对照组的20.00%，差异有统计学意义（Plt;0.05）。结论：乌司他丁治疗急性胰腺炎，疗效安全，充分改善炎症因子水平，有效控制病情发展，降低不良反应发生率，值得临床推广。 　　关键词：急性胰腺炎 ;乌司他丁;临床疗效 　　Abstract： objective： to analysis the clinical curative effect of ulinastatin treatment of acute pancreatitis. Selection methods： clinical data of 60 patients admitted in our hospital with acute pancreatitis， randomly divided into treatment group and control group， 30 cases each. ， control group treated with conventional treatment group implementation of ulinastatin treatment， compared two groups of patients with clinical efficacy. Results： treatment group total effective rate of 93.33% is significantly higher than the control group 76.67%， the difference was statistically significant （P lt; 0.05）. Treatment group abdominal pain relief time， pancreatic edema disappeared， active for the first time defecation time were significantly shorter than the control group， the difference was statistically significant （P lt; 0.05）. CRP， TNF - a group after treatment， IL - 15， IL - 10 levels significantly lower than the control group， the difference was statistically significant （P lt; 0.05）. CRP， TNF - a group after treatment， IL - 15， IL - 10 levels significantly lower than the control group， the difference was statistically significant （P lt; 0.05）. The incidence of adverse reactions was 6.67% treatment group was obviously less than 20.00% in the control group， the difference was statistically significant （P lt; 0.05）. Conclusion： ulinastatin treatment of acute pancreatitis， curative effect of safety， fully improve the inflammatory factor levels， effective control of the disease， reduce the incidence of adverse reactions， worthy of clinical promotion. 　　Keywords： ac