微刺激方案在卵巢储备功能减退患者不同年龄组中临床结局分析.docVIP

微刺激方案在卵巢储备功能减退患者不同年龄组中临床结局分析 　　[摘要] 目的 探讨微刺激方案在不同年龄的卵巢储备功能减退（DOR）患者中的临床应用及临床结局。方法 整群选取回顾性分析自2012年1月―2015年9月在该院生殖中心行微刺激方案的卵巢储备功能减退患者，共679例，按照年龄分为3组，A组，421个周期，年龄≤35岁，B组，153个周期，35岁0.05），而在临床妊娠率、自然流产率有显著差异，A组的临床妊娠率及自然流产率分别为31.43%和20.45%，B组为10%和33.33%，C组为18.18%和62.5%（P0.05）。 结论 微刺激方案适用于卵巢储备功能减退的患者，特别是年轻患者，仍有较高的临床妊娠率。 　　[关键词] 卵巢储备功能减退；微刺激方案；体外受精-胚胎移植 　　[中图分类号] R714.8 [文献标识码] A [文章编号] 1674-0742（2016）05（c）-0034-03 　　[Abstract] Objective To study the clinical application and clinical outcome of mini-stimulation protocol programs in patients with decreasing ovarian reserve of different age groups. Methods 697 cycles from patients with decreasing ovarian reserve receiving mini-stimulation protocol programs in the reproductive center of our hospital from January 2012 to September 2015 were retrospectively analyzed， and the patients were divided the group A whose age≤35 with 421 cycles， the group B whose age was between 35 and 40 with 153 cycles and the group C whose age≥40 with 105 cycles， and the retrieved oocyte number， number of transferable embryos， cycle cancellation rate， clinical pregnancy rate of fresh cycle and spontaneous abortion rate of them were compared. Results There was no obvious difference in the retrieved oocyte number， number of transferable embryos and cycle cancellation rate between the three groups（P0.05）， but there was an obvious difference in the clinical pregnancy rate and spontaneous abortion rate between the three groups，31.43% and 20.45% vs 10% and 33.33% vs 18.18% and 62.5%（P0.05）. Conclusion Mini-stimulation protocol program applies to the patients with decreasing ovarian reserve， especially the young patients， and it is still has a higher clinical pregnancy rate. 　　[Key words] Decreasing ovarian reserve； Mini-stimulation protocol program； In vitro fertilization-embryo transplantation 　　卵巢低反应是当今辅助生殖技术领域的一个难题，特别是对于卵巢储备功能减退的患者和高龄患者。卵巢对超促排卵药物的反应不良导致获卵率低，可移植胚胎少，周期取消率高，临床妊娠率低，反复多次致经济花费大。微刺激方案用少量药物刺激卵巢，不良反应少，经济花费少，可重复性高，对于年轻患者，累积妊娠率并不低。为探讨微刺激方案在不