抗心磷脂抗体及抗β2―GP1抗体与妊娠期高血压疾病患者围生儿结局相关性研究.docVIP

抗心磷脂抗体及抗β2―GP1抗体与妊娠期高血压疾病患者围生儿结局相关性研究 　　【摘要】 目的：通过定量对比妊娠期高血压疾病患者与正常孕妇血清抗心磷脂抗体（anticardiolipin antibody，ACA）及抗β2-GP1抗体水平，并记录围生儿结局，分析ACA、抗β2-GP1抗体滴度值与围生儿结局的相关性。方法：选取150例妊娠期高血压疾病患者作为研究对象，其中轻度93例，重度 　　47例；另选取同时期住院分娩的150例正常孕妇作为正常对照组；对比妊娠期高血压疾病患者与正常孕妇血清ACA及抗β2-GP1抗体滴度值，详细记录围生儿结局，采用线性回归分析，分析血清ACA及抗β2-GP1抗体滴度值与围生儿结局的相关性。结果：重度妊娠期高血压疾病组、轻度妊娠期高血压疾病组和正常对照组血清ACA-IgG、ACA-IgM和抗β2-GP1抗体滴度值比较，差异均有统计学意义（P0.05）；重度妊娠期高血压疾病组胎儿生长受限、早产、围生儿死亡、胎盘早剥、死胎的发生率均高于轻度妊娠期高血压疾病组，轻度妊娠期高血压疾病组大于正常对照组，三组不良围生儿结局发生率比较差异有统计学意义（P0.05）；ACA-IgG、ACA-IgM与胎儿生长受限呈正相关（P0.05），ACA-IgG、ACA-IgM和抗β2-GP1抗体与早产呈正相关（P0.05），抗 　　β2-GP1抗?w与围生儿死亡呈正相关（P0.05）；而ACA-IgG、ACA-IgM和抗β2-GP1抗体两两间存在显著性相关（P0.05）。结论：ACA及抗β2-GP1抗体与妊娠期高血压疾病患者的围生儿结局具有相关性，对妊娠期高血压疾病患者检测ACA及抗β2-GP1抗体，对于预测不良围生儿结局的发生具有一定依据。 　　【关键词】 抗心磷脂抗体； 抗β2-GP1抗体； 妊娠期高血压疾病； 围生儿结局 　　Correlation between Anti-cardiolipin Antibody，Anti-β2-GP1 Antibody in Patients with Pregnancy-induced Hypertension and Perinatal Outcome/LIANG Lin，YAN Yu.//Medical Innovation of China，2017，14（03）：001-005 　　【Abstract】 Objective：To explore the relevance of ACA and anti-β2-GP1 antibody titer with perinatal outcome through the quantitative comparison of anti-cardiolipin antibody（ACA） and β2-GP1 antibody level between hypertensive disorders complicating pregnancy patients and normal pregnant women，and recording of perinatal outcome.Method：A total of 150 cases with hypertensive disorders complicating pregnancy were selected as objects.Among them，93 cases were mild and 47 cases were severe.150 normal pregnant women were selected as the normal control group.Serum ACA level and anti-β2-GP1 antibody concentration were compared between hypertensive disorders complicating pregnancy patients and normal pregnant women，and perinatal outcomes were recorded in detail.By means of linear regression，the relationship of serum ACA level and anti-β2-GP1 antibody concentration with perinatal outcome were analyzed.Result：There were statistical significances for serum ACA-IgG，ACA-IgM and anti-β2-GP1 antibody titer among