标准化免疫治疗对哮喘儿童屋尘螨特异性IgG4和肺功能影响.docVIP

标准化免疫治疗对哮喘儿童屋尘螨特异性IgG4和肺功能影响 　　[摘要] 目的 探讨标准化免疫治疗对哮喘儿童屋尘螨特异性IgG4和肺功能的影响。 方法 选取本院2012年6月～2013年6月收治的68例哮喘患儿作为研究对象，随机分成实验组和对照组，各34例。实验组给予标准化免疫治疗，对照组给予单纯吸入性糖皮质激素治疗。比较两组的屋尘螨特异性IgG4及肺功能改善情况。 结果 实验组的FEV1、PEF水平显著高于对照组，差异有统计学意义（P0.05）。实验组治疗后的IgG4水平显著高于对照组，差异有统计学意义（P0.05）。 结论 标准化免疫治疗对哮喘儿童屋尘螨特异性IgG4和肺功能具有十分重要的影响，临床应引起足够重视。 　　[关键词] 标准化免疫治疗；儿童；哮喘；屋尘螨特异性IgG4；肺功能 　　[中图分类号] R725.6 [文献标识码] A [文章编号] 1674-4721（2015）09（b）-0091-03 　　Influence of specific immunotherapy on house dust mite specific IgG4 and pulmonary function of asthmatic children 　　LIU Lian-xiang HE Li LI Yan-fang 　　Department of Pediatrics，Maternal and Child Care Service Centre of Futian District in Shenzhen City，Shenzhen 518000，China 　　[Abstract] Objective To explore the influence of specific immunotherapy on house dust mite specific IgG4 and pulmonary function of asthmatic children. Methods 68 children with asthma from June 2012 to June 2013 in our hospital were selected and randomly divided into the experimental group and the control group，34 cases in each group.The experimental group was given specific immunotherapy，the control group was given inhaled corticosteroids.Then house dust mite specific IgG4 and pulmonary function in two groups was compared. Results The level of FEV1，PEF in the experimental group was higher than that in the control group，with significant difference （P0.05）.The level of IgG4 after treatment in the experimental group was higher than the control group，with significant difference （P0.05）. Conclusion Specific immunotherapy has significant impact on house dust mite specific IgG4 and pulmonary function of asthmatic children，and clinical should cause enough attention. 　　[Key words] Specific immunotherapy；Children；Asthma；House dust mite specific IgG4；Pulmonary function 　　哮喘是临床上常见的慢性气道炎症，多由T淋巴细胞、嗜酸粒细胞、肥大细胞等多种细胞参与所致，临床多表现为胸闷、喘息、气促、咳嗽等，儿童属于高危人群[1]。近年来，有关研究显示，血清IgE水平上升及活性增强属于诱发Ⅰ型变态反应性疾病的起始环节，在这一环节中，IgG4具有介导及抑制Ⅰ型变态反应的作用[2-3]。本研究对本院收治的哮喘患儿进行平行对照研究，旨在探讨标准化免疫治疗对哮喘儿童屋尘螨特异性IgG4和肺功能的影响。 　　1 资料与方法