消渴方加减联合二甲双胍片对2型糖尿病患者HOMA―IR及血液流变学影响.docVIP

消渴方加减联合二甲双胍片对2型糖尿病患者HOMA―IR及血液流变学影响 　　[摘要]目的 探讨消渴方加减联合二甲双胍片对2型糖尿病（T2DM）患者胰岛素抵抗指数（HOMA-IR）及血液流变学的影响。方法 将2015年1月～2017年5月因T2DM（气阴两虚型）于我院就诊的90例患者纳入研究并依据随机数字表法分组，对照组45例采用二甲双胍片、格列美脲降血糖治疗，观察组45例联合消渴方加减治疗，12周为1个疗程。比较两组的临床疗效。结果 治疗后，两组患者的空腹血糖（FBG）、餐后2 h血糖及HOMA-IR水平均低于对照组，差异有统计学意义（P0.05）；治疗后，观察组的纤维蛋白原（Fib）、D-二聚体水平低于对照组，差异有统计学意义（P0.05）。结论 消渴方加减联合二甲双胍片治疗T2DM的效果显著，可改善胰岛素抵抗，调节血糖水平，优于单用西药治疗，值得推广。 　　[关键词]消渴方；二甲双胍片；2型糖尿病；胰岛素抵抗；血液流变学 　　[中图分类号] R587.1 [文献标识码] A [文章编号] 1674-4721（2017）12（b）-0138-03 　　[Abstract]Objective To investigate the influence of addition and subtraction of Xiaoke Prescription combined with Metformin Tablets on HOMA-IR and hemorheology in patients with type 2 diabetes mellitus （T2DM）.Methods Ninety patients with T2DM （Qi-Yin deficiency） treated in our hospital from January 2015 to May 2017 were enrolled in the study and were grouped according to the random data table method，Forty-five patients in the control group were treated with Metformin tablets and Glimepiride to decrease the blood glocose，On this basis，forty-five patients in the observation group were combined with Xiaoke Prescription，and 12 weeks were a course of treatment.The clinical efficacy between the two groups was compared.Results After treatment，the fasting blood glucose （FBG），postprandial 2 h blood glucose and HOMA-IR level of the two groups were lower than those of the control group，and the difference was statistically significant （P0.05）.The fibrinogen （Fib） and D-dimer in the observation group were lower than those in the control group，and the difference was statistically significant （P0.05）.Conclusion The effect of Xiaoke Prescription combined with Metformin Tablets in the treatment of T2DM is significant and can improve insulin resistance，regulate blood glucose level，and it is better than the use of western medicine alone，it is worth promoting. 　　[Key words]Xiaoke Prescription；Metformin Tablets；Type 2 diabetes mellitus；Insulin resistance；Hemorheology 　　2型糖尿病（T2DM）是一?N以血糖水平升高为特点，多饮、多食为主要临床