电子鼻咽镜联合核磁共振在鼻咽癌放疗后复查临床观察.docVIP

电子鼻咽镜联合核磁共振在鼻咽癌放疗后复查临床观察 　　【摘要】 目的：探究电子鼻咽镜联合核磁共振在鼻咽癌患者放疗后对病情变化的诊断价值，为患者的复查寻找最精确的手段。方法：将2014年1月-2015年1月收治的80例经放疗后来本院复查的鼻咽癌患者纳入本次研究，对所有患者分别进行间接鼻咽镜+鼻咽核磁共振检查（对照组）与电子鼻咽镜+鼻咽核磁共振检查（观察组），探讨两种方式对患者病情变化的诊断价值。结果：观察组患者鼻咽部改变总数的检出率明显高于对照组，且在对鼻腔、鼻窦以及声带改变比较中同样优于对照组，两组比较差异均有统计学意义（P0.05）。结论：采用电子鼻咽镜联合鼻咽核磁共振对鼻咽癌患者放疗后进行复查，能有效提供细胞水平的定量与定性信息，同时敏感的鉴别鼻咽癌放疗后残留、纤维化斑块与肿瘤复发的情况，具有较高的临床推广价值。 　　【关键词】 电子鼻咽镜； 核磁共振； 鼻咽癌； 放疗 　　【Abstract】 Objective：To explore diagnostic value of nasopharyngoscope combining NMR on changes in disease conditions of patients with nasopharyngeal carcinoma， and to look for the most accurate method for the re-examination on patients.Method：80 patients with nasopharyngeal carcinoma upon radiotherapy from January 2014 to January 2015 were selected as research subjects， all patients were subjected to indirect nasopharyngeal endoscope+nasopharyngeal NMR （control group） and nasopharyngoscope+nasopharyngeal NMR examination （observation group），the diagnostic value of changes in patients’ conditions was explored.Result：The detection rate of nasopharyngoscope+nasopharyngeal NMR examination on the change total of nasopharynx in patients was significantly higher than that of indirect nasopharyngeal endoscope+nasopharyngeal MRI， and it was better than that of indirect nasopharyngeal endoscope+nasopharyngeal MRI in the nose， sinuses and vocal cord change，the differences were statistically significant（P0.05）.Conclusion：The re-examination of nasopharyngoscope combining nasopharyngeal NMR in patients with nasopharyngeal carcinoma after radiotherapy is capable of effectively providing quantitative and qualitative information cellular level，and sensitively identify conditions of residues of nasopharyngeal carcinoma after radiotherapy，fibrosis plaque and tumor recurrence， delivering high clinical value. 　　【Key words】 Nasopharyngoscope； NMR； Nasopharyngeal Carcinoma； Radiotherapy 　　鼻咽癌在我国南方的发病率较高，可达25/10万～30/10万，且具有逐年上升的趋势[1]。鼻咽癌对于放射线的敏感性较高，所以临床上的首选治疗方式为放疗。但放疗患者多伴有组织粘连与纤维增生等，形态难以恢复正常，且出现纤维