脑血管病继发癫痫病临床研究.docVIP

脑血管病继发癫痫病临床研究 　　[摘要] 目的 评价药物治疗脑血管病继发癫痫疗效，分析疾病发病特征，总结治疗经验。方法 方便选取2014年2月―2016年1月，神经内科收治的脑血管病继发癫痫患者作为研究对象，入选对象72例，随机对照分组，对照组、观察组各入组36例，两组患者均治疗原发卒中病、康复治疗，癫痫发作时，部分给予镇定剂，对照组选择抗癫痫药物CBZ、OXC、VPA、VLA治疗，单用或联用，观察组联合或单独应用左乙拉西坦治疗，24周为1个疗程，进行视频脑电图检查，评价治疗效果。结果 观察组控制率25.0%、控制+显效合计率80.6%高于对照组2.8%、33.33%，无效率11.1%低于对照组33.3%，差异均有统计学意义（P0.05）；治疗后，观察组与对照组癫痫放电指数低于治疗前，观察组低于对照组，差异具有统计学意义（P0.05）。结论 脑血管病继发癫痫病多见脑叶区损伤者，多表现为强制-痉挛发作、单纯部分性发作；常规抗癫痫药物疗效常难以让人满意，左乙拉西坦疗效较好。 　　[关键词] 癫痫；脑血管病；继发病；临床治疗 　　[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742（2016）11（a）-0088-03 　　[Abstract] Objective To evaluate the drug in the treatment of cerebral vascular disease and secondary epilepsy disease characteristics， summarize the treatment experience. Methods Convenient selection from February 2014 to January 2016， Department of neurology were cerebral vascular disease and secondary epilepsy patients as the research object， selected 72 cases， as control group， the control group， the observation group and the group of 36 cases， two groups of patients were treated for primary stroke， rehabilitation treatment， seizures， given tranquilizer， and the control group， select the antiepileptic drug carbamazepine（CBZ）， OXC， VPA， VLA treatment， Single or combined use， the observation group joint or separate application of levetiracetam therapy， 24 weeks A period of video EEG， and the treatment effect was evaluated. Results Observation group control rate of 25.0%， control + effective total rate is 80.6% higher than that of the control group 2.8%，33.33%，11.1% efficiency is lower than that of the control group was 33.3%， differences were statistically significant （P 0.05）； after treatment， observation group and the control group of epileptic discharge index were lower than those before treatment， observation group than that in the control group， the difference is statistically significant（P 0.05）. Conclusion Cerebral vascular disease and secondary epilepsy disease more common lobe of brain damage， more performance for the forced seizu