脉冲联合表阿霉素神经后支毁损治疗带状疱疹后神经痛临床效果分析.docVIP

脉冲联合表阿霉素神经后支毁损治疗带状疱疹后神经痛临床效果分析 　　【摘要】 目的：探讨脉冲联合表阿霉素神经后支毁损治疗带状疱疹后神经痛的临床疗效。方法：选取2016年5月-2017年6月本院收治的带状疱疹后神经痛患者80例为研究对象，均行脉冲联合表阿霉素神经后支毁损治疗，观察患者不同时间段VAS评分、PSQI评分和临床疗效，同时记录患者术后可能发生的并发症。结果：患者术后即刻、术后1周、术后3个月及术后6个月的VAS评分和PSQI评分均明显低于术前，差异均有统计学意义（P0.05）；患者术后3个月显效率为94%，明显高于术后即刻的70%，差异有统计学意义（P0.05）；无一例患者出现感染、气胸、呼吸循环抑制等并发症。结论：脉冲联合表阿霉素神经后支毁损在运用表阿霉素毒性作用使神经变性作用的同时，通过神经调控产生生物学效应，调控中枢神经的疼痛介质以改善中枢敏化，有效缓解带状疱疹后神经痛的临床症状，提高患者生活水平，具有重要的临床意义，值得推广和应用。 　　【关键词】 脉冲； 表阿霉素； 带状疱疹后神经痛 　　Pulse Combined with Epirubicin Nerve Ablation in the Treatment of Postherpetic Neuralgia/WANG Xiaoying，WANG Ling，LI Juanjuan，et al.//Medical Innovation of China，2017，14（32）：123-126 　　【Abstract】 Objective：To investigate the effect of pulse combined with Epirubicin nerve ablation in the treatment of postherpetic neuralgia.Method：80 patients with postherpetic neuralgia treated in our hospital from May 2016 to June 2017 were selected as the subjects，they were given pulse combined with Epirubicin nerve ablation and the VAS score at different times was observed，PSQI score，clinical efficacy and the possible complications after the operation were recorded.Result：VAS scores and PSQI scores of the patients immediately，1 week after operation，3 months after operation and 6 months after operation were significantly lower than those of before the operation，the difference were significant（P0.05）.The effective rate was 94% at 3 months after operation，significantly higher than 70% of immediately after surgery，the difference was significant（P0.05）.There were no complications such as infection，pneumothorax，respiratory and circulatory depression in 1 case.Conclusion：Pulse combined with epirubicin nerve damage in the use of toxic effects of Epirubicin make neurodegenerative effects.At the same time，the biological effect of the nerve regulation，regulate the pain medium of central nervous system to improve central sensitization，the clinical symptoms of postherpetic neuralgia are effectively relieved，improving the living standard of t