脑梗死患者脂蛋白相关磷脂酶A2相关研究.docVIP

脑梗死患者脂蛋白相关磷脂酶A2相关研究 　　DOI：10.16662/j.cnki.1674-0742.2017.23.033 　　[摘要] 目的 探讨脑梗死患者脂蛋白相关磷脂酶A2（LP-PLA2）水平与血管性认知障碍（VCI）的相关性。方法 便利选取2016年1月―2017年5月该院收治的90例脑梗死患者为研究对象，全部患者均在病程3 d内抽取静脉血检测血清LP-PLA2水平，依据检测结果将入选病例分为实验组（LP-PLA2175 ng/mL，45例）和对照组（LP-PLA2≤175 ng/mL，45例）。治疗后随访，以蒙特利尔认知量表（MoCA）评价两组认知功能，统计两组VCI发病率。结果 实验组MoCA评分（22.1±2.7）分，VCI发病率57.8%，与对照组比较差异有统计学意义（P0.05）。结论 LP-PLA2高水平可能是脑梗死患者VCI不良预后的临床标志物，加强LP-PLA2观察对VCI临床诊断具有一定参考价值。 　　[关键词] 脑梗死；脂蛋白相关磷脂酶A2；血管性认知障碍 　　[中?D分类号] R749 [文献标识码] A [文章编号] 1674-0742（2017）08（b）-0033-03 　　Correlation between Lipoprotein-related Phospholipase A2 （LP-PLA2） Level and Vascular Cognitive Impairment （VCI） in Patients with Cerebral Infarction 　　ZHANG Man-yi 　　Department of Neurology， Yixing People’s Hospital， Yixing， Jiangsu Province， 214200 China 　　[Abstracts] Objective This paper tries to investigate the correlation between lipoprotein-related phospholipase A2 （LP-PLA2） level and vascular cognitive impairment （VCI） in patients with cerebral infarction. Methods Convenient selection 90 patients with cerebral infarction from January 2016 to May 2017 were selected and extracted venous blood serum LP-PLA2 level within 3 days of course， and were divided into the experimental group（LP-PLA2175 ng/mL， 45 cases） and the control group（LP-PLA2≤175 ng/mL， 45 cases） according to the test results. The cognitive function of the two groups was evaluated by the Montreal Cognitive scale（MoCA） after the treatment， and the incidence of VCI of the two groups was statistically analyzed. Results The MOCA score was（22.1±2.7）points and the incidence of VCI was 57.8% in the experimental group， which was statistically significant compared with the control group.（P0.05）. Conclusion LP-PLA2 high level may be a clinical marker of VCI prognosis in patients with cerebral infarction， and strengthening LP-PLA2 observation has certain reference value for VCI clinical diagnosis. 　　[Key words] Cerebral infarction； Lipoprotein-related phospholipase A2； Vascular cognitive impair