脑梗死患者血浆同型半胱氨酸表达及其临床意义.docVIP

脑梗死患者血浆同型半胱氨酸表达及其临床意义 　　[摘要] 目的 探讨脑梗死患者血浆同型半胱氨酸（Hcy）的表达及其临床意义。 方法 选择2011年6月～2012年5月首都医科大学丰台教学医院神经内科治疗的脑梗死患者150例（脑梗死组）及同期体检中心健康体检者90例（对照组），采用循环酶方法测定并比较其血浆Hcy浓度。 结果 脑梗死组Hcy为（18.99±7.86）μmol/L，对照组Hcy为（10.94±4.47）μmol/L，脑梗死组Hcy浓度显著高于对照组，差异有统计学意义（P 0.05）。 结论 脑梗死患者血浆Hcy水平明显升高，Hcy是脑梗死发生的危险因素之一。 　　[关键词] 脑梗死；同型半胱氨酸；临床意义 　　[中图分类号] R743.33[文献标识码] A[文章编号] 1673-7210（2014）06（a）-0060-03 　　 　　Levels of plasma homocysteine in patients with acute cerebral infarction and its clinical significance 　　CHENG Zhiguo 　　Fengtai Teaching Hospital of Capital Medical University, Beijing 100071, China 　　[Abstract] Objective To investigate the expression of plasma homocysteine in patients with acute cerebral infarction and its clinical significance. Methods 150 patients with cerebral infarction from June 2011 to May 2012 in Department of Neurology, Fengtai Teaching Hospital of Capital Medical University were selected as cerebral infarction group, 90 cases in healthy physical examination center in the same term were chosen as control group. The plasma Hcy concentration was measured by enzymatic cycling method and compared. Results The Hcy concentration in cerebral infarction group were (18.99±7.86) μmol/L. The Hcy concentration in control group were (10.94±4.47) μmol/L. The Hcy in cerebral infarction group was higher than that in control group, the difference was statistically significant (P 0.05). Conclusion Plasma homocysteine levels in patients with cerebral infarction are significantly increased, homocysteine is a risk factor for cerebral infarction. 　　[Key words] Cerebral infarction; Homocysteine; Clinical significance 　　脑卒中俗称脑中风或脑血管意外，指向大脑供血的血管在各种诱发因素下发生狭窄，闭塞或破裂，导致临床表现为偏瘫、失语等局部神经功能缺失的一组急性脑血管病的总称，分为缺血性脑卒中和出血性脑卒中。缺血性脑卒中又称为脑梗死，是指局因血液循环障碍，引起局部脑组织缺血、缺氧而发生的软化坏死，大约占所有脑卒中的80%。脑梗死作为神经系统的常见疾病，是目前导致人类死亡的三大主要疾病之一，也是最常见的致死和致残原因之一。近年来血浆同型半胱氨酸（Hcy）在心脑血管疾病的发生、发展中的作用越来越受到重视[1-3]。Hcy即2-甲基4-巯基丁酸，是一种含硫基的人体非必需氨基酸，是蛋氨酸循环的重要环节及蛋氨酸代谢的中间产物，在生物体内由甲硫氨酸进行转甲基反应时脱甲基生成，即：S-腺苷甲硫氨酸→S-腺苷同型半胱氨酸，后者的SH基经胱硫醚与丝氨酸的羟基交