脑梗死患者血清同型半胱氨酸和D二聚体检测临床意义.docVIP

脑梗死患者血清同型半胱氨酸和D二聚体检测临床意义 　　[摘要] 目的 研究脑梗死患者血清同型半胱氨酸和D-二聚体检测的临床意义。方法 将2012年6月～2013年6月我院收治的脑梗死患者40例列为研究对象，根据CT或MRI所示病灶大小将其分为大面积脑梗死组（病灶直径5 cm）15例、小面积脑梗死组（病灶直径5 cm）25例；另选同期在我院进行健康体检正常人40例作为对照组，比较脑梗死组与正常对照组血清Hcy、D-二聚体的水平，及比较不同梗死病灶患者血清Hcy、D-二聚体水平。结果 40例脑梗死组患者血清Hcy、D-二聚体水平分别为（15.18±2.73）μmol/L，（1.68±0.45）mg/L，分别明显高于正常对照组，组间分别比较，差异具有统计学意义 （P0.05）。15例大面积脑梗死灶组Hcy、D-二聚体水平分别为（17.23±3.46）μmol/L，（1.72±0.35）mg/L，均明显高于小面积脑梗死病灶组，组间分别比较，差异具有统计学意义（P0.05）。 结论 脑梗死是一个复杂的病理过程，其各种指标均处在动态变化之中，同型半胱氨酸与D-二聚体的水平与脑梗死的发生及发展密切相关，将HCY和D-二聚体作为常规检测项目之一，有利于减少脑梗死的发生率。 　　[关键词] 同型半胱氨酸；D-二聚体；脑梗死； 梗死灶面积 　　[中图分类号] R743.33 [文献标识码] B [文章编号] 1673-9701（2013）36-0018-02 　　The clinical significance of detection serum homocysteine and D-dimmer for patients with cerebral infarction 　　LI Yingying 　　Department of Neurology，the Central Hospital of Liaoning Province， Liaoyang 111000，China 　　[Abstract] Objective To study the clinical significance of serum homocysteine and D-dimer testing in patients with cerebral infarction. Methods From June 2012 to June 2013 in our hospital， 40 patients with cerebral infarction as the research object， based on CT or MRI lesion size shown were divided into a large area of cerebral infarction group （lesion diameter 5 cm） 15 cases， a small area of cerebral infarction group（lesion diameter 5 cm）25 cases； alternative for the same period in the hospital for 40 cases of normal healthy control group，cerebral infarction group compared with normal control group，serum Hcy，DD levels and different infarcts serum Hcy，DD levels were compared. Results 40 cases of cerebral infarction patients serum Hcy，DD levels were 15.18 ± 2.73 μmol/L，（1.68±0.45）mg/L，respectively，was significantly higher than the normal control group， the difference was significant（P 0.05）. 15 cases of large infarct group Hcy， DD levels were（17.23±3.46）μmol/L，（1.72±0.35）mg/L，respectively，was significantly higher than the group of small infarct size，the difference was significant between the two groups（P0.05）. Conclusion Cerebr