肝素联合多巴胺治疗新生儿寒冷损伤综合征疗效分析.docVIP

肝素联合多巴胺治疗新生儿寒冷损伤综合征疗效分析 　　【摘要】目的 观察分析肝素联合多巴胺治疗新生儿寒冷损伤综合征的临床疗效，总结其临床价值。方法 选取我院2009年4月至2011年4月102例新生儿寒冷损伤综合征的患儿，随机分为观察组和对照组，各51例，对照组给予常规抗感染、复温、补液及能量支持等治疗，观察组在常规治疗的基础上加用肝素联合多巴胺治疗，观察对比两组治疗效果。结果 观察组中治愈34例，显效10例，有效6例，无效1例，总有效率86.27%；对照组中治愈23例，显效11例，有效14例，无效3例，总有效率66.67%，两组疗效比较差异显著（P＜0.05），具有统计学意义。结论 肝素联合多巴胺治疗新生儿寒冷损伤综合征的临床疗效确切，治愈率高，能明显降低病死率，不良反应小，安全可靠，值得在临床上合理推广应用。 　　【关键词】肝素联合多巴胺 新生儿寒冷损伤综合征 临床疗效 　　中图分类号：R722.1文献标识码：A文章编号：1005-0515（2011）12-007-02 　　Heparin and dopamine treatment of neonatal cold injury syndrome analysis 　　【Abstract】Objective To observe the analysis of heparin and dopamine in the treatment of neonatal cold injury syndrome, clinical efficacy, summarize its clinical value. Methods Our hospital from April 2009 to April 2011 102 cases of neonatal cold injury syndrome in children, randomly divided into two groups and the control group, all 51 cases, the control group received conventional anti-infective, thawing, rehydration and energy support, treatment, observed in the conventional treatment group based on the use of heparin and dopamine, observed and compared two groups of treatment. Results The cure in 34 cases, 10 cases markedly effective in 6 cases, 1 patient, the total efficiency of 86.27%; the control group cured 23 cases, 11 cases markedly effective in 14 cases, 3 cases, the total effective rate 66.67 % difference between the two groups was significant (P 0.05), with statistical significance. Conclusion heparin and dopamine treatment of neonatal cold injury syndrome, clinical efficacy, the cure rate is high, can significantly reduce mortality, side effects, safe and reliable, it is reasonable in clinical application. 　　【Key words】heparin and dopamine effects of neonatal cold injury syndrome 　　新生儿寒冷损伤综合征，是指由于寒冷引起的??体低体温和多器官的功能受损，其严重的患儿会导致出现有皮肤的硬肿。其主要发生在每年的1、2、11、12月[1]，由于此阶段气温较低，新生儿的中枢神经对体温调节不够成熟，而其体表面积相对较大，血管较为丰富，同时，其皮下脂肪较少，机体的热量容易散出[2]。在寒冷的环境下，如果保暖不当，就会导致新生儿的热量快速减少。一旦产生的热量不能抵偿新生儿失去的热量时，就会导致体温下降，出现各种临床表现。我院临床医生在治疗新生儿寒冷损伤综合征时，联合使用了肝素与多巴胺治疗，效果较好，现报