老年2型糖尿病患者血糖和胰岛素抵抗对CA199水平影响.docVIP

老年2型糖尿病患者血糖和胰岛素抵抗对CA199水平影响 　　[摘要] 目的 探讨老年2型糖尿病患者血糖和胰岛素抵抗对CA199水平的影响。 方法 选取2010年6月～2012年12月于广西医科大学第一附属医院收治的89例老年2型糖尿病患者（老年糖尿病组）和75例中年2型糖尿病患者（中年糖尿病组），两组再按照CA199水平分为CA199阴性组（CA19937 U/mL）和CA199阳性组（CA199≥37 U/mL）4个亚组，即老年糖尿病CA199阴性组（55例）、老年糖尿病CA199阳性组（34例）、中年糖尿病CA199阴性组（46例）、中年糖尿病CA199阳性组（29例）。比较各组空腹血糖（FBG）、餐后2小时血糖（2hPBG）、空腹胰岛素（FIns）、餐后2 h胰岛素（2hIns）、糖化血红蛋白（HbA1c），CA199，胰岛素敏感指数（ISI）和胰岛素抵抗指数（HOMA-IR），将CA199水平与以上各参数进行Pearson相关分析。 结果 老年糖尿病组和中年糖尿病组中，CA199阳性组的FBG、2hPBG、FIns、2hIns和HOMA-IR均高于CA199阴性组，而ISI低于CA199阴性组，差异有统计学意义（P 0.05）。老年糖尿病CA199阳性组的FBG、FIns、2hIns、HbA1c高于中年糖尿病CA199阳性组，差异有统计学意义（P 0.05）。相关分析显示，中年糖尿病组的血清CA199水平与FBG、2hPBG、HbA1c、HOMA-IR呈正相关，与ISI呈负相关。老年糖尿病组的血清CA199水平与FBG、2hPBG、2hIns、HbA1c、HOMA-IR呈正相关，与ISI呈负相关。 结论 血清CA199升高与血糖代谢异常及胰岛素抵抗密切相关。 　　[关键词] 糖尿病；糖代谢；胰岛素抵抗；糖类抗原CA199 　　[中图分类号] R587.1[文献标识码] A[文章编号] 1673-7210（2014）06（c）-0049-04 　　 　　Influence of blood glucose and insulin resistance on CA199 level in elderly patients with type 2 diabetes mellitus 　　YANG Xi LIU Hong▲ 　　Division of Geriatrics Endocrinology, the First Affiliated Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region, Nanning 530021, China 　　[Abstract] Objective To investigate the relations of CA199 level with blood glucose and insulin resistance in elderly patients with type 2 diabetes mellitus. Methods The 89 elderly inpatients and 75 middle-aged inpatients with type 2 diabetes in Division of Geriatrics Endocrinology, the First Affiliated Hospital of Guangxi Medical University from June 2010 to December 2012 were divided into elderly diabetes group (89 cases) and middle-aged diabetes group (75 cases). And the two groups were divided into CA199 negative group (CA199 37 U/mL) and CA199 positive group (CA199≥37 U/mL), the four groups were elderly diabetes CA199 negative group (55 cases), elderly diabetes CA199 positive group (34 caes), middle-aged diabetes negative group (46 cases) and middle-aged diabetes positive group (19 cases). The levels of Fasting blood glucose (FBG), 2