解脲支原体沙眼衣原体感染致女性不孕临床分析.docVIP

解脲支原体沙眼衣原体感染致女性不孕临床分析 　　【摘要】目的 探讨解脲支原体(UU)、沙眼衣原体(CT)感染与女性不孕症发生的关系及治疗。方法 598例女性不孕症患者作为观察组,579例有正常生育史育龄妇女作为对照组。取宫颈分泌物采用PCR方法检测两组标本中UU和CT的感染情况。结果 不孕症组宫颈分泌物中UU阳性率为69.06%(413/598),CT12.04%(72/598),UU和CT混合阳性率为18.90%(113/598);对照组中UU阳性率为3.1%(18/579),CT阳性率为1.0%(6/579),UU和CT混合阳性率为0。两组间比较差异均有极显著性(P0.01)。结论 UU和CT感染与女性不孕症发生有密切关系。对不孕症患者应常规进行衣原体和支原体检测及药敏试验,可以针对性地进行治疗,提高治愈率。 　　【关键词】 解脲支原体;沙眼衣原体;女性不孕症 　　【Abstract】Objective To investigate the association between infection with Ureaplasma urealyticum(UU) and Chlamydia trachomatis(CT) infection with female infertility.Method 598 samples of cervical secretions from female patients with infertility were collected for observation. Another 579 samples from normal women in child-bearing age serve as control.UU and CT were detected by polymerase chain reaction(PCR). Result For the cervical secretions from patients with infertility, the percentage of samples having UU, CT, and both UU and CT were 69.06%, 12.04% and 18.90%, respectively. In the control group, the percentage of samples having UU, CT, and both UU and CT were 3.1%, 1.0% and 0, respectively. The infection rate in patients with infertility is significantly greater than the normal subject (P0.01). Conclusion The occurrence of female infertility is associated with asymptomatic infections of Ureaplasma urealyticum and Chlamydia trachomatis. Pairs of infertility patients should be routinely chlamydia and mycoplasma detection and drug susceptibility testing, can be targeted for treatment, increase cure rates. 　　【keyword】Ureaplasma urealyticum Chlamydia trachomatis female infertility 　　中图分类号:R711.6 文献标识码:A 文章编号:1005-0515(2010)03-063-02 　　 　　不孕症在不同国家、不同地区、不同种族中发病率不尽相同。世界卫生组织估计有7%~15%的夫妇受到不孕症的困扰。我国大约有8%的育龄夫妇存在不孕的问题。随着生育年龄的延迟,感染性疾病的传播,不孕症患者呈逐年上升趋势,越来越引起人们的重视。不孕症的发病原因很多,其中女性原因造成的不孕约占60%。大量研究表明,在女性不孕的原因中,除先天性、内分泌及免疫因素外,慢性生殖道感染是女性不孕的重要原因[1]。解脲支原体(UU)、沙眼衣原体(CT)均属于寄生于生殖道的原核细胞型微生物,现将对我院门诊598例解脲支原体、沙眼衣原体感染致女性不孕进行临床分析,报告如下: 　　1 资料与方法 　　1.1 一般资料 2007年8月至2009年8月来我院不孕症门诊就诊的不孕女性患者1246例中因解脲支原体