颈动脉支架成形术治疗老年人颈内动脉狭窄疗效及及安全性相关因素分析.docVIP

颈动脉支架成形术治疗老年人颈内动脉狭窄疗效及及安全性相关因素分析 　　摘要 目的 分析?i动脉支架成形术（CAS）治疗老年颈内动脉狭窄的疗效、安全性及其相关因素。方法 回顾性纳入2012年1月―2014年6月上海市徐汇区中心医院神经内科收治的152例65岁以上颈内动脉颅外段狭窄患者。分为介入组73例（接受CAS）及对照组79例（接受药物治疗），分组依据患者是否同意接受CAS。对两组患者进行1年随访，观察患者NIHSS及mRS评分变化，比较两组临床疗效。应用logistic回归分析影响65岁以上颈内动脉颅外段狭窄的老年患者进行CAS治疗安全性的相关因素。结果 患者在3、6个月及1年随访时，介入组NIHSS与mRS平均秩次均低于药物组（P0.05）。对介入组进行分析，结果显示，经CAS治疗后发生脑血管不良事件的患者其既往脑梗死史、冠心病、高血压、高脂血症、术前合并非干预脑动脉狭窄，以及术后残余狭窄比例明显高于未发生患者（P0.05）。多因素logistic分析显示，既往脑梗死史、术前合并非干预脑动脉狭窄及术后残余狭窄，为CAS治疗后脑血管不良事件发生的独立预测因子。结论 CAS治疗老年颈内动脉颅外段狭窄的有效性与安全性高。既往脑梗死史、术前合并非干预脑动脉狭窄及术后残余狭窄是术后脑血管事件发生的危险因素，介入治疗前应加以评估。 　　关键词：颈内动脉狭窄；颈动脉支架成形术；支架内再狭窄；脑梗死；危险因素 　　中图分类号：R743.3 文献标志码：A 　　Carotid artery stent angioplasty for treatment of internal carotid artery stenosis in the elderly： analysis on its efficacy and related factors of safety 　　YU li-na， LIU jin-xiang， XI gang-ming 　　Department of Neurology， Shanghai Xuhui Central Hospital， Shanghai 200031， China 　　Abstract： Objective To study the efficacy and safety of carotid artery stenting（CAS） in elderly patients with internal carotid artery stenosis and its related factors. Methods Between January 2012 and July 2014， a total of 152 patients（over 65 years of age）with carotid artery stenosis were enrolled in this study， of whom 79 patients received drug treatment （control group） and 73 patients received CAS （intervention group）.The two groups were followed up for one year. The patients’ scores of mRS（the modified Rankin Scale） and NIHSS（ the National Institute of Health Stroke Scale ） were observed and compared in the curative effect between the two groups. By means of logistic regression were analyzed the related safety factors in CAS treatment for elderly patients over 65 with extracranial stenosis of internal carotid artery. Results Both the median mRS （P0.05）at one year follow-up. And logistic regression analysis showed that the previous history of cerebral infarction， residual stenosis or combined un-interferential cerebral arterial stenosis were all independent pr