应用ET评价血压对颈动脉内皮功能和腔隙性.docVIP

应用ET评价血压对颈动脉内皮功能和腔隙性 　　[摘要] 目的 应用血管回声跟踪技术（E-Tracking，ET）评价血压对颈动脉内皮功能及腔隙性脑梗死的影响。 方法采用随机抽样法抽取我院2009年2月～2013年8月采用ET技术及颅脑MRI检查的门诊及住院患者，其中正常血压与各级高血压各60例，将各组间ET参数中的血管僵硬度（β）、弹性模量（Eρ）、血管顺应性（AC）及不稳定粥样硬化斑块及MRI检测出的腔隙性梗死进行比较。 结果 血管僵硬度（β）、弹性模量（Eρ）、不稳定斑块及腔隙性梗死统计数据随血压升高而升高，血管顺应性（AC）随血压升高而降低。 结论 血压升高与血管内皮功能损伤及腔隙性脑梗死密切相关，在高血压早期，即使颈动脉未发生形态及结构的改变，血压已成为血管内皮功能损伤的独立危险因素。 　　[关键词] 血管回声跟踪技术；高血压；血管内皮功能；腔隙性脑梗死 　　[中图分类号] R743.3[文献标识码] B[文章编号] 1673-9701（2014）18-0151-03 　　 　　The efficacy of assessing blood pressure by E-Tracking on carotid artery endothelial function and lacunar infarction 　　SUN Fenzhen YAN Xiaoli 　　Neurology Department, Elderly Care Hospital of Qingyang City in Gansu Province, Qingyang 745000, China 　　[Abstract] Objective To observe the efficacy of assessing blood pressure by E-Tracking on carotid artery endothelial function and lacunar infarction. Methods Sixty cases from normal blood pressure group and high blood pressure were out patients or hospitalized patients in the elderly care hospital from February 2009 to August 2013, and were all checked by ET and MRI. β, Eρ, AC, atherosclerotic plaques and lacunar infarction were compared. Results Vascular stiffness (β), modulus of elasticity (Eρ), unstable plaques and lacunar infarction statistics increased with increased blood pressure. Vascular compliance(AC) decreased with increased blood pressure. Conclusion The rise of blood pressure was closely related with vascular endothelial injury and lacunar infarction. Even though carotid artery is not obvious pathological change in the early hypertension, blood pressure has become an independent risk factor for vascular endothelial injury. 　　[Key words] E-Tracking；High blood pressure; Vascular endothelial function; Lacunar infarction 　　 目前我国卒中患者正以每年8.7%速度递增，高血压是脑卒中的重要独立危险因素[1]，动脉功能改变的早期发现是心脑血管疾病早期检测的首要目标。ET技术是近年应用于临床的超声新技术，能够动态跟踪和描记动脉壁的运动轨迹，输入血压数值后自动计算出各项指标,可在血管形态和结构发生改变之前早期发现动脉硬化改变，是一项无创评估动脉功能指标，具有操作方便、重复性好的特点，测量精确度达0.007～0.013 mm，明显优于传统的检测方法[2]。本研究主要选择与血压有关的血管僵硬度（β）、弹性模量（