铜绿假单胞菌耐药性临床调查和防治对策.docVIP

铜绿假单胞菌耐药性临床调查和防治对策 　　[摘要] 目的：主要研究我院铜绿假单胞菌的分布、分离率及其对15种抗菌药的体外耐药谱，指导临床合理选用抗菌药。方法：按常规方法培养分离后，经MicroscanautoSCAN4微生物分析仪鉴定细菌，用K-B法做药敏实验。细菌耐药性采用χ2检验。结果：铜绿假单胞菌临床分离构成2002年居第2位，2003～2006年居第1位，对多种抗菌药严重耐药，ICU和神经外科耐药率明显高于其他病区。5年间铜绿假单胞菌对15种抗菌药物的耐药率存在增高趋势，变化显著。结论：我院铜绿假单胞菌的临床分离率及耐药率5年来明显上升。防治其产生的根本方法是，加强对该菌的耐药性监测及各环节的严格消毒，合理使用抗菌药。 　　[关键词] 铜绿假单胞菌；耐药性；防治对策 　　[中图分类号] R446 [文献标识码]A [文章编号]1673-7210（2007）12（b）-044-02 　　 　　Clinical research of the resistance of pseudomonas aerugimosa and its prevention 　　WU De-zhen,WANG Qian 　　(Xinxiang Central Hospital of Henan Province ,Xinxiang 453000,China) 　　[Abstract] Objective:To investigate the distribution and isolation rate of pseudomonas aeruginosa in our hospital and its antibioticy to 15 kinds of bear the medicinal circumstance. Guiding the clinical rational use of antibiotics. Methods:The pseudomonas aeruginosa were cultured, isolated andidentified by microscanauto SCAN4MicrobeIdentification System, The antifungal susceptibility was detected byK-B method. The isolation rate were detected with χ2 test.Results:The isolation rate of psendomonsa aeruginosain 2002 ranked the 2nd among the bacteria isolated .But it ranked the 1st from2003 to 2006 respectively. Pseudomonas aeruginosa was seriously resistant to many antimicrobial drugs.The antimicrobial resistance rates in ICU and nervous surgical ward werehigher than those in other wards. Conclusion:The isolation rate and antimicrobial resistance of pseudomonas aeruginosa were obviously increasing in our hospital during the last five years, surveillance of antimicrobialresistance of bacterias，strictly sterilizing measures and rational use of antibiotics are methodsfor its prevention. 　　[Key words]Pseudomonas aerusinosa; Antimicrobial resistance; Prevention measures 　　 　　铜绿假单胞菌(pseudomonas aerginosa,PA)为医院内感染最常见的致病菌之一。目前，随着广谱抗菌药的广泛应用，其耐药性变得越来越严重，给临床治疗带来极大困难。因此，对其分布情况及耐药性监测日益受到重视。探讨PA感染的防治对策，对减少PA感染的发生、提高医疗质量、改善患者预后有重要意义。现对我院2002年1月～2006年12月分离到的PA的分布、分离率及耐药性进行回顾分析，并提出防治对策，以便为临床合理使用抗菌药物，有