儿童急性白血病RIZ1基因表达及启动子甲基化状态的实验分析-儿科学专业论文.docxVIP

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儿童急性白血病RIZ1基因表达及启动子甲基化状态的实验分析-儿科学专业论文.docx

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儿童急性白血病RIZ1基因表达及启动子甲基化状态的实验分析-儿科学专业论文

目录中文摘要······························································································· 1 Abstract 5 前言································································································ 10 第一部分 RIZ1 基因在儿童急性白血病的表达改变前言···························································································· 14 材料与方法······················································································ 15 结果···························································································· 21 讨论···························································································· 26 参考文献························································································· 28 第二部分急性白血病 RIZ1 基因启动子区域甲基化状态前言···························································································· 31 材料与方法······················································································ 32 结果···························································································· 40 讨论···························································································· 43 参考文献························································································· 45 第三部分 DNA 甲基转移酶活性变化与 RIZ1 表达相关研究前言···························································································· 47 材料与方法······················································································ 48 结果···························································································· 54 讨论···························································································· 56 参考文献························································································· 58 全文总结····························································································· 61 综述································································································ 62 英文缩略词表············