雾化吸入沐舒坦联合酮替芬治疗小儿咳嗽 变异性哮喘的的疗效观察.docVIP

雾化吸入沐舒坦联合酮替芬治疗小儿咳嗽 变异性哮喘的的疗效观察 　　【摘要】#8195;目的#8195;探讨雾化吸入沐舒坦(盐酸氨溴索注射液)联合酮替芬治疗小儿咳嗽变异性哮喘的临床治疗效果。方法#8195;81例咳嗽变异性哮喘患儿, 根据治疗方法随机分为治疗组47例和对照组34例, 对照组：口服酮替芬, 年龄5岁, 1 mg/次, 2次/d；年龄≤5岁, 0.5 mg/次, 2次/d；治疗组在口服酮替芬基础上, 加用沐舒坦注射液15 mg雾化吸入, 15 min/次, 2次/d。疗程为7 d。结果#8195;治疗组治愈31例, 显效10例, 好转5例, 无效1例；对照组治愈17例, 显效6例, 好转6例, 无效5例。两组患儿治疗后均取得较好疗效, 治愈组治愈、显效及总有效率明显优于对照组, 差异有统计学意义(P0.05)。 结论#8195;雾化吸入沐舒坦联合酮替芬治疗小儿咳嗽变异性哮喘疗效显著, 值得临床推广应用。 　　【关键词】#8195;雾化吸入；小儿咳嗽变异性哮喘；沐舒坦；酮替芬 　　 　　Effect observation on aerosol inhalation mucosolvan combined with ketotifen in the treatment of children with cough variant asthmaCHENG Zhi-hui. Zhanjiang Center People’s Hospital, Zhanjiang 524037, China 　　【Abstract】#8195;Objective#8195; To investigate the clinical effect of aerosol inhalation mucosolvan combined with ketotifen in the treatment of children with cough variant asthma. Methods#8195;Selected 81 cases of cough variant asthma and randomly divided them into treatment group and control group, control group: oral ketotifen, Age5 years old, 1mg, twice a day; age5 years old, 0.5 mg, twice a day; treatment group on the basis of oral ketotifen for mucosolvin injection 15 mg, 15 min/time, twice a day for 7 days. Results#8195;Cure, effective and total effictive rate of treatment group were better than control group, difference was statistical significance(P0.05). Conclusion#8195;Aerosol inhalation mucosolvan combined with ketotifen have a significant effect in the treatment of children with cough variant asthma, so it is worthy of clinical application. 　　【Key words】#8195;Aerosol inhalation; Cough variant asthma; Mucosolvan; Ketotifen小儿咳嗽变异性哮喘(cough variant asthma, CVA)又称过敏性支气管炎、咳嗽性哮喘及隐匿性哮喘, 是哮喘的一种特殊类型, 唯一的症状就是慢性咳嗽, 无痰或少痰, 反复发作1个月以上, 运动后加剧, 大多数夜间或清晨发作是本病的主要特征。小儿任何年龄均可发病, 其中学龄期儿童多见。本院自2011年4月~2013年4月采用雾化吸入沐舒坦联合酮替芬治疗小儿咳嗽变异性哮喘, 取得满意疗效, 现报告如下。 　　1 资料与方法 　　1. 1一般资料选择本院自2011年4月~2013年4月咳嗽变异性哮喘患儿81例, 所有患儿诊断符合中华医学会分会呼吸病组制定的儿童支气管哮喘防治常规［1］, 根据治疗方法随机分为治疗组和对照组。治疗组47例, 其中男28例, 女19例, 年龄2~11岁, 平均年龄(7.4±1.7)岁, 病程(8.5±1.4)个月；对照