体外受精―胚胎移植后自然流产原因剖析.docVIP

体外受精―胚胎移植后自然流产原因剖析 　　【摘要】 目的：探讨在体外受精-胚胎移植（IVF-ET）助孕妊娠后发生自然流产的原因。方法：回顾性分析本中心行IVF-ET后临床妊娠的患者485例，分为早期流产（A组）、晚期流产（B组）及持续妊娠及分娩（C组），三组患者的年龄、不孕年限、Gn总量、Gn天数、获卵数、移植胚胎数、移植日内膜厚度、胚胎质量、受精方式及既往有无流产病史进行比较和分析。结果：A、B组患者的年龄、移植胚胎数均高于C组，差异均有统计学意义（P0.05）。结论：高龄女性、有既往流产史的患者在IVF-ET助孕妊娠后发生自然流产的风险较高，而多胎妊娠是发生晚期自然流产的高危因素。 　　【关键词】 体外受精-胚胎移植； 早期流产； 晚期流产 　　Analysis of Spontaneous Abortion Cause after in Vitro Fertilization-embryo Transfer/ZHANG Dan，TAN Li，ZHAO Dong-mei.//Medical Innovation of China，2015，12（24）：031-033 　　【Abstract】 Objective：To investigate the in vitro fertilization-embryo transfer （IVF-ET）occurs causes of spontaneous abortion after pregnancy.Method：485 patients with clinical pregnancy after the center line of IVF-ET were retrospective analyzed，and divided into early abortion （group A），late abortion （group B） and ongoing pregnancy and childbirth patients （group C）.The age， duration of infertility， total of Gn， few days of Gn， number of oocytes retrieved， number of embryos transferred， endometrial thickness on transplant day， embryo quality， fertilization methods and previous history of miscarriage of three groups were compared and analyzed.Result：The age and number of embryos transferred of group A and group B were higher than group C， the differences were statistically significant（P0.05）.Conclusion： The elderly woman and have a past history of miscarriage after IVF-ET patients in assisted reproduction pregnancy are higher risk of spontaneous abortion， and multiple pregnancy is a risk factor for the occurrence of late spontaneous abortion. 　　【Key words】 In vitro fertilization-embryo transfer； Early abortion； Late abortion 　　First-author’s address：Second Affiliated Hospital of Zhengzhou University，Zhengzhou 450014，China 　　doi：10.3969/j.issn.1674-4985.2015.24.011 　　体外受精-胚胎移植（In vitro fertilization-embryo transfer，IVF-ET）技术是目前治疗不孕不育的重要手段，通过该技术能让许多的不孕夫妇成功受孕，但胚胎种植率低、妊娠后流产率高一直困扰着临床工作者。不断深入研究体外受精-胚胎移植（IVF-ET）周期中发生早期流产和晚期流产的原因，对其采取针对性的预防和干预有重要的临床价值。有研究文献报道IVF-ET的流产率为10%～20%，有些报