肺组织定居记忆T细胞在过敏性哮喘中的作用-免疫学专业论文.docxVIP

万方数据 万方数据 目 录 中文摘要····································································································1 英文摘要····································································································6 英文缩写··································································································13 研究论文 肺组织定居记忆 T 细胞在过敏性哮喘中的作用 前言··································································································14 材料与方法······················································································16 结果··································································································31 附图··································································································36 讨论··································································································54 结论··································································································56 参考文献··························································································57 综述 组织定居记忆 T 细胞的产生以及在保护性免疫和炎性疾病中 的作用··························································································59 致谢··········································································································77 个人简历··································································································78 中 中 文 摘 要 PAGE 10万方数据 PAGE 10 万方数据 肺组织定居记忆 T 细胞在过敏性哮喘中的作用 摘 要 目的：组织定居记忆 T 细胞（Tissue-resident memory T cells, TRM）是 记忆 T 细胞的新亚群，初始 T 细胞在抗原激活后会迁移到多种外周非淋 巴组织器官，在原位分化成特异性的记忆 T 细胞，而定居下来，不再经 过淋巴细胞再循环，当在该组织中遇到相同抗原时能迅速发生应答，在保 护性免疫作用中独立于循环记忆 T 细胞。目前在皮肤、肺、阴道粘膜、 大脑，甚至在淋巴组织中都已发现了 TRM 的存在，其中 CD8+TRM 细胞的 表型为：CD69+CD103+，CD4+TRM 细胞的表型为：CD69+CD11a+。 过敏性哮喘是一种常见的、复杂的、多基因调控的慢性呼吸系统疾病， 其特征是慢性的气道炎症以及非特异性的气道高反应。过敏性哮喘的炎症 应答由多种炎症细胞（如嗜酸性粒细胞、肥大细胞、T 淋巴细胞、巨噬细 胞、中性粒细胞和气道上皮细胞等）和炎症因子共同参与，其临床表现为 反复发作的喘息、气急、胸闷、咳嗽等症状。目前，全世界将近 3 亿人口 患有过敏性哮喘，中国就有约 3000 万患者，且其发病率仍然在以每十年 近 50%的速度增加，严重危害人们的健康。 过敏性哮喘属于再次免