环境敏感型介孔分子筛复合材料的制备与载药释药性能化学专业论文.docxVIP

重庆大学硕士学位论文英文 重庆大学硕士学位论文 英文摘要 PAGE PAGE IV ABSTRACT Drug Controlled-release solved the inadequate problems which caused by the traditional way, such as the drug concentration in receptor was instability, drug half-life was short, the role of rate was low and easily to cause side effects, it resulted the long-term maintenance of effective drug concentration in vivo, and greatly improved the efficiency and effectiveness of the drug. Mesoporous silica materials with lots of advantages, such as large surface area, pore uniformity, pore size can be adjusted, the surface can be modificated easily and so on, and good biocompatibility, non-toxic properties make it an ideal material for drug-delivery, therefore, it is very suitable for the carrying of drugs, proteins and other biological molecules. In addition, in biomedical applications, smart intelligent hydrogels can be used for encapsulation of enzymes, controlled drug release, etc., it is also a good drug-carrier material. Make smart intelligent hydrogels composite with mesoporous materials, the composite material can get the characteristics of the two materials, it will has a broader prospect in application. In this paper, we took the cetyltrimethy-lammonium bromide (CTAB) as templating agent, tetra ethoxy silane (TEOS) as silica source, the mesoporous silica material MCM-41 was synthesized by microwave synthesis. By taking the acrylic acid (AA), N-Isopropylacrylamide (NIPAAm) as monomers to composite with MCM-41, we obtained the pH, temperature, and pH-temperature sensitive composite material. By means of FTIR, X-ray diffraction, N2 adsorption-desorption, thermo gravimetric analysis and so on, the structure of the material was characterized, and the environmental sensitivity of the material was also measured. Hydrochlorothiazide, a kind of a compression diuretic drugs, was used as a model drug, and through the liquid UV method, the drug loading and release properties of the composite material was studied . MCM-41/PA