降血糖药物普兰林肽的固相合成-中药学专业论文.docxVIP

降血糖药物普兰林肽的固相合成 Solid phase synthesis of Pramlintide 研 究 生：韩 月 学 号年 级：2009 级 导 师：王良友 副教授 赵桂琴 副教授 学科专业：中药学 所在系部：中药研究所 研究方向：药物化学 研究起止日期：2010 年 9 月～2012 年 3 月 论文提交日期：2012 年 3 月 目 录 中文摘 要··························································································· ················1 英 文 摘 要 ··························································································· ················4 英文缩 写··························································································· ················7 研究论文 降血糖药物普兰林肽的固相合成 前 言··························································································· ················8 材料与方 法··························································································· ····9 结 果··························································································· ···············18 附 图··························································································· ···············23 附 表··························································································· ···············36 讨 论··························································································· ···············42 结 论··························································································· ···············43 参考文 献··························································································· ·······45 综 述··························································································· ···············47 致 谢··························································································· ···············54 个人简 历··························································································· ···············55 中 中 文 摘 要 PAGE PAGE 10 降血糖药物普兰林肽的固相合成 摘 要 世界卫生组织统计数据表明，全球糖尿病患者已超过 3.6 亿人，我国 糖尿病患者人数居世界第一，现有降糖药物种类较多，降糖机制不尽相同， 但是仍不能满足临床用药的需要。2005 年 3 月，FDA 批准普兰林肽 （Pramlintide）注射剂用于成人 1 型和 2 型糖尿病，并取得良好的临床效 果。普兰林肽是 1 型和 2 型糖尿病