结核散加化疗治疗肺结核的临床与实验研究-中西医结合专业论文.docxVIP

y．≤D组90摘 y．≤D组90 摘 要 目的观察结核散治疗肺结核的临床疗效，并探讨其作用机制。方法 根据中医学“补土生金”、“肝病实脾”等原理，在参苓白术散基础上， 自拟结核散以补益脾肺，扶正杀虫。在同一条件下，用结核散配合化疗 (治疗组)与安慰剂配合化疗(对照组)分别治疗肺绩莛60例，观察并比 较二组的临床疗效。对结核散作用机制也作了初步实验探讨。(结果 治疗 组结核病人的一般症状消失时间为II．2--+4．7天；在强化期内，化疗药物毒 副反应发生率为14人次；痰菌阴转率为93．33％；耐药菌株发生率为5％：病 f1 变x线明显吸收率为68．30％；空洞闭合率为77．80％；全部疗程结束后，其 综合疗效达96．7％。与对照组比较均具有显著性差异(PO．01，或PO． 05)。实验研究表明，结核散可显著提高激素免疫抑制小鼠的sRBc— jf DTH值，明显减轻CTX所致小鼠脾器官充卓水肿，降低spleen index，抑 菌实验表明有一定的直接抑制结核菌作用。)结论结核散配合化疗治疗肺 结核具有显著临床效果，其作用机制与提高机体免疫功能、对抗化疗药物 的组织损害、改善微循环和直接抑菌作用有关。 关键词 结核散；肺结核；中西医结合治疗 _ Clinical Clinical and Experimental Study on the Treatment of Tuberculosis with JieHaiSan and Chemotherapy Specialit?,The integration ofthe traditional Chinese and Western medicine Gl·amIate：jlangHongYao TIlloJ·：Prot：ZhaoZiXJan Abstract Objecti、re To observe the clinical effects of JieHaiSan(JHS)in the treatnlent of Tuberculosis，and to explore its mechanism．Methods Based on”reflfforcing me spleen before the liver diseases!’and”w reinforcing earth for generating metal”．．mS was prepared Under standard regimens．JHS was used to treat 60 patients of Tuberculosis (TB)as treatment group，and other 60 patients with chemotherapy onb,，as control group Clinical effects were compared with tlie two gl·Otips The relevant experiment was also conducted．Results In treatment group．the general symptom eliminating thne was l 1．2±4．7 dags；in intensive phase．the adverse reaction occured in 1 4 CaSeS in all；sputum negative conversion rate was 93．33％；drug resistance rate WaS 5％：X—ray obviously absorbing rate was 68．3％；cavity closing rate was 77．8％；after treatment completed，cure rate was 96．67％They were superior to those of control group(p0．0 1，or p0 os)． Experimental study showed that JHS could raise SRBC—DTH．10wer spleen index，and it had direct bactericidal effect．Conclusion JHS is j obviously effective in treating TB，the mechanism possibly la37S on adjusting ilmnune fimction、anti—toxicity、improving blood circulation and dh‘ect bacte