贲门腺癌、癌旁及正常胃粘膜组织中SHP-1和EGFR的表达及其相关性研究.pdfVIP

英文摘要 4Inadenocarcinomatissue ofSHP一1in group，theexpression I／II ofdifferentiation grade group(20／55，36．4％)werehigher thanthat III ofin 1，1 gradegroup(4／32．9％)，p0．05．The stainratesofEGFRin III positive gradegroup(24／31，77．4％) were thanthatof I obviouslyhigher gradegroup(5／15，33．3％)， 1．The stainrateofEGFRin p0．0 positive tissuewith metastasis much lymph group(37／49，75．5％)was thaninwithoutmetastasis higher lymph P0．01．InTNM rateofEGFRin Ill／IV stagegroups，the stage thanthoseofin I／II 1，76．5％)were group(39／5 higher stage ofSHP一1and group(12／35，34．3％)，P0．01．The expression EGFRwasnotcorrelatedwithinvasion size，tumor depth，tumor embolusin and useindex． vessel，age，sexcigarette Conclusions：1The stainrateofSHP一1incarcinoma positive tissue was lowerthanthatin and groupobviously paraneoplastic normal that mucosa indicatedthedeactivation gastric group．It ofSHP一1 wasinvolvedin in gene tumorigenesis adenocarcinomaofhuman cardia．