肺炎支原体肺炎患儿治疗前后血清IL2,IL8和β防御素2检测的临床意义.docxVIP

肺炎支原体肺炎患儿治疗前后血清IL-2JL-8和B -防御素-2检 测的临床意义 夏永英 (江苏省连云港市连云区妇幼保健所 222042) 【摘要】冃的 探讨了肺炎支原体肺炎患儿治疗前后血清IL-2JL-8和beta;? 防御素?2水平的变化及临床意义。方法 应用放射免疫法和酶联法对33例肺炎 支原体肺炎患儿进行了治疗前后血清IL-2JL-8和beta;■防御素?2水平检测，并与 35名正常健康儿作比较。结果 肺炎支原体肺炎患儿在治疗前血清IL?2,beta;? 防御素?2水平非常显著地低于正常儿组(Plt;0.01)，而IL-8水平又非常显著地高 于正常儿组(Plt;0.01)z经治疗2周后则与正常人比较无显著性差异(Pgt;0.05), 血清IL?8水平与IL-2, beta;?防御素?2水平呈显著免相差 (r=-0.4782/-0.5018/Plt;0.01) ?结论 血清 IL-2, IL-8 和beta;-防御素?2 参与了 肺炎支原体感染的全过程，检测这些细胞因子的变化有助于诊断，治疗和预后, 具有一定的临床价值。 【关键词】 肺炎支原体肺炎 白细胞介素?2 白细胞介素?8 beta; ■防 御素?2 【中图分类号】R446 【文献标识码】A 【文章编号】2095-1752 (2014) 02-0240-02 Clinical Significanee of measurement changes of Serum IL-2JL-8 and Beta-Defensin?2 levels after treatment in pediatric patients with mycoplasma pn eum onia. Maternal and Child Health Lianyun District, Lianyungang City， YongyingXia. [Abstract] Objective:To explore the Clinical Significance of changes of Serum IL-2JL-8 and Beta-Defensin?2 levels after treatment in pediatric patients with mycoplasma pneumonia.Methods:Serum IL-2,IL-8(with RIA),Serum Beta-Defensin?2 (with ELISA) levels were determined in 33 patients and 35 normal healthy children?Results:Before treatment,Serum IL-乙Beta-Defensin-2 levels were Sign讦icantly lower than those in Controls(Plt;O.Ol),but serum IL-8 levels were significantly higher than those in controls (Plt;0.01).after treatment for 2 weeks the levels in patients manifested no more different from those in controls(Pgt;0.05),Serum IL-8 levels was negative correlated with serum IL-2 levels ,beta-Defensin-2 levels(r=-0.4782,-0.5018,Plt;0.01).Conclusions:The cytokines IL-2,IL-8 and keta-Defensin-2 might participate in the whole process of my coplasma infection,monitoring the changes of these cytokines could be healptul to the diag no sis, treatme nt and prog nosis of the diseases and provides certai n clin ical values. 【Key words］ Mycoplasma pneumonia interleukin-2(IL-2) interleukin-8(IL-8) Beta-defe nsin-2 肺炎支原体肺炎为学龄前儿童的常见的一种肺炎，其发病机理至今尚未完全 阐明［1］。本文对我所经临床明确诊断的33例肺炎支原体肺炎患儿进行了治疗前 后血清IL-2,