磺丁基醚-β-环糊精的制备及其对阿奇霉素包合作用研究-药物化学专业论文.docxVIP

II II ABSTRACT Now, the solubilization of non-aqueous drugs gives rise to extensive attention. The solubility of drug not only directly influences the dissolution of drugs in vivo and bioavailability, but also seriously influences the clinical curative effect of concentration dependent drugs. Recently, it was found that CD can accommodate different kinds of non-aqueous drugs in the cavity, forming host-guest inclusion complexes, therefore, the dissolubility of non-aqueous drugs can be improved remarkably, and also a series of problems of non-aqueous drugs preparation can be solved. However, it