基质金属蛋白酶-9和高敏C-反应蛋白与2型糖尿病早期大血管病变的相关分析-内科学专业论文.docxVIP

中文摘要基质金属蛋白酶．9和高敏C一反应蛋白 中文摘要 基质金属蛋白酶．9和高敏C一反应蛋白 与2型糖尿病早期大血管病变的相关研究 摘要 目的 探讨基质金属蛋白酶．9(MMP一9)和高敏C．反应蛋白 (hsCRP)与2型糖尿病(T2DM)早期大血管病变发生的关系 设计方案前瞻性病例对照研究 研究地点中南大学湘雅二医院代谢内分泌研究所 研究对象T2DM患者 研究方法170例T2DM患者接受降糖、降压、降脂等综合性强化 治疗，观察其治疗1年后大血管病变的发生情况。其中有24例出现大 血管病变，以此作为观察组；根据年龄、性别、血压、血脂等因素进 行配对，选择24例未发生大血管病变的患者作为对照组。分别比较观 察组和对照组强化治疗前后的MMP一9、hsCRP水平变化以及观察组与 对照组之间的MMP．9、hsCRP水平变化差异。 结果①两组患者强化治疗一年后的Mh伸．9水平较治疗前均有升 高(Po．05)，且观察组上升的幅度高于对照组(P0．05)。②与基线 情况进行比较，一年后观察组的hsCRP水平有升高趋势，相反在对照 组hsCRP水平呈下降趋势。虽然二者的差异均无统计学意义(P0．05)， 但组间的hsCRP水平差异具有显著性(PO．05)。 结论@T2DM患者早期大血管病变的发生与其血浆MMP．9、 hsCRP浓度升高有关，其中与MMP-9的关系更为密切。②常规的糖 尿病综合性治疗无法阻止T2DM患者血浆MMP．9水平的上升。 关键词2型糖尿病，大血管病变，基质金属蛋白酶．9，高敏性 C．反应蛋白 硕士学位论文 硕士学位论文 英文摘要 The study of relationship between matrix metalloproteinases一 9，high sensitivity C—reactive protein and macrovascular complications in type 2 diabetics ABSTRACT objective：To investigate whether matrix metalloproteinases 9 (MMP一9)，high-sensitivity C—reactive protein(hsCRP)have an effect on the development of macrovascular complications in type 2 diabetics (T2DM)． Design：Prospective case—control study． Setting：The Second XiangYa Hospital，Central South university, Changsha，China． Participants：Type 2 diabeteics． Methods：One hundred and seventy patients with T2DM received comprehensive treatment on hyperglycemia，hyperlipidemia，and hypertension for one year．There are 24 individuals(observed group)in which early macrovascular complications were observed at the end of treatment．Paired、vitll age，gender,blood pressure，plasma lipids，24 diabetics without any masrovascular complications were taken as the control group．Levels of MMP-9 and hsCRP in two groups before and after the treatment were compared respectively．Differences between the groups were also compared． Results：①Elevated levels ofMMP一9 were observed in both．groups after comprehensive treatment for one ye