基质金属蛋白酶-9基因多态性与颈动脉粥样硬化微栓子形成的相关性分析-神经病学专业论文.docxVIP

宁夏医科大学硕士研究生学位论文中文摘要 宁夏医科大学硕士研究生学位论文 中文摘要 II II 因素（OR=10.000，P0.05）。结论：MMP-9 基因启动子 C1562T 基因多态性与微栓子 形成密切相关。 关键词 基质金属蛋白酶-9（MMP-9），缺血性脑血管病，颈动脉粥样硬化不稳定斑 块，微栓子 宁夏医科大学硕士研究生学位论文英文摘要 宁夏医科大学硕士研究生学位论文 英文摘要 III III Relationship between polymorphism of Matrix metalloproteinases-9 gene with the form of carotid atherosclerosis micro embolus ABSTRACT Background: Cerebrovascular disease (also called stroke) is the high rate of morbidity , and 67.3% - 80.5% of the ischemic stroke. Atherosclerosis is considered to be pathology foundation of ischemic cerebrovascular disease, its pathogenic mechanism is vascular stenosis and plaque off the embolism.The function of Matrix metalloproteinase (MMPs) is degrading and shaping the extracellular matrix (ECM) and maintain the dynamic balance of the extracellular matrix. MMPs expression increased, which can make the fibre composition of degradation, promote the artery atheromatous plaque formation, and cause it to burst and the formation of thrombus. Shedding of blood clots which can lead to cerebral infarction and other related disease. In the MMPs family,MMP-9 expression is the most widely, higher than other types of MMPs .To seek more prediction method,this research which take MMP-9 gene polymorphism as the base to study the relationship of unstable plaque and formation of micro embolus, further explore the pathogenesis of carotid atherosclerosis especially unstable plaque，and genetic characteristics of micro embolus. Objective： To investigate the relationship between polymorphism at promoter of C1562T of Matrix metalloproteinases-9 (MMP-9) with positive of Carotid atherosclerosis micro embolus to provide the help for cerebrovascular disease prevention, early diagnosis and treatment. Methods：A diagnosis of carotid ultrasound ischemic cerebrovascular were done for disease patients, and they were screened with 120 patients who have unstable plaques with carotid atherosclerosis . Further, color transcranial doppler ultrasound