基质金属蛋白酶26（MMP-26）在肿瘤、胎盘、绒毛和子宫中的表达-生理学专业论文.docxVIP

论文摘要璀质金属赁自酶26(MMP一26)址坡近发现的MMP家族成员。l|IjU钉笑 论文摘要 璀质金属赁自酶26(MMP一26)址坡近发现的MMP家族成员。l|IjU钉笑 MMP一26的报道很少。人们仪知其，fi化拍阡，刈j¨其生聩‘、病理作Ⅲ秽啉4竹研冗 尚处于起步阶段。为此，作者运用免疫堂Ii旧J逊、照位杂交和RT—PCR技术检测 了人月经周期子宫内膜、人正常绒毛、人，7。历腑擞、人了腺癌、人J7I洲I蠕、 多种人卵巢癌。恒河猴女t-娠早期j=寓、人鼠fH!娠V删第4、5、6天ffi、大鼠动 情周期于寓、小鼠妊娠早期第3、4、5人J，”和小鼠动情周jlj】jl宫t”MMP一26 的表达俏况。，纪果发现MMP一26蛋一腰衲人A盘、了”J)』l瘸、绒毛及火鼠妊姒 早期第4、5、6天子宫有表达，其中笫4、5人强表达，笫6天弱表达。MMP一26 mRNA仅商：人F富腺瘸的问质和血管内皮以及恒功f猴妊娠‘≠期(第i2天，了守 内膜腺h皮中检测到，而白：人增生期二r髓内)瓤j 3经期予7i内膜、绝经期予¨内 膜、人黏液性卵巢癌、浆液性：卵巢癌、交界性卵巢癌、人子宫肌瘤、人lr常绒毛 (6周、8周)、大鼠妊娠早期第4、5、6天f寓、大鼠动情周期f宵、小鼠妊娠 早期第3、4、5天子寓和小鼠动情周期Ij=_t{r{J均没有检测到阳性信号。可见 MMP一26可能参与早期妊娠、分娩、胂癌生K以及肿瘤生长过程r{·的血管新“： 结果表明，划于MMP家族其他成员来说，MMP一26的表达是比较崩部的，其作 蹦r—j能迎为争 。 AbstractMMP一26 Abstract MMP一26 is a new member of MMPs family There is sparse research work Oil MMP一26 and little is known about its physiological and pathological roles Using Western blot，in situ hybridization and RT—PCR the author found MMP一26 protein in human placenta，human vilIi，human hysteromyoma and rat uterus during early pregnancy MMP一26 protein is strongly expressed in rat uterus on day 4 and day 5 and is weakly expressed on day 6 MMP一26 mRNA was detected in hunlan endometrial adenocarcinoma stronla and vessel epithelia and in pregnant Rhesus monkey uterus glandular epithelium(day 12)No positive signal was found in human endometrium during menstral pbase，menopause phaSC and menopause，human ovarian serous， mucinous and borderline tumors，human hysteromyoma，human villi(6 weeks and 8 weeks)，rat uterus during early pregnancy(day 4，day 5，day回and estrolls cycle， mouse uterus during early pregnancy(day 3，day 4，day 5)and estrous cycle It is concluded that：MMP一26 may participate in early pregnancy，parturition and tulnoi‘ growth and angiogenesis；In contrast to other MMPs，MMP一26 is restricted to limited parts and its function may be more specific Key words：MMP一26，tumor，uterus，ovary,pregnancy 缩略词表AbbreviatiOns 缩略词表 AbbreviatiOns AP一1 Activator protein一1 激活吲子蛋白．1 BCIP 5-bromo—-4—-chloro—-3一indolyl—phosphate 5一溴4一氯一3一吲哚