急性高低剂量饮酒对健康人脑部影响磁共振弥散张量和频谱分析-像影医学与核医学专业论文.docxVIP

ABSTRACT Purpose：To assess the values of diffusion tensor imaging (DTI) and MRS in detecting the acute effects of alcohol on healthy young adult human brains. This study was also to correlate results of DTI and MRS in healthy subjects before and after alcohol intake. Materials and Methods： Sixteen healthy volunteers (age 25-33y，man=8，woman=8) were randomly divided into two groups: low doses group(0.45 g/kgbw, n=8) and high doses group( 0.65 g/kgbw, n=8).They were studied with conventional MR imaging, MRS and DTI using the same imaging parameters prior to and 1 h, 2 h, 3 h after the initiation of alcohol administration so that each subject could serve as its own control. Multivoxel Chemical shift imaging (CSI) and DTI were performed on a 1.5 T MRI scanner. FA and ADC values were measured in centrum semiovale, frontal lobe, genu corporis callosi, splenium corporis callosi, internal capsule, external capsule, thalamus and vermiform process of cerebellum. Choline (Cho), creatine and N-acetylaspartate (NAA) were detected in centrum semiovale. A region of interest was positioned in the white matter of the Multivoxel CSI data were processed and the metabolite ratios estimated. DTI parameters corresponding to the exact region of tissue excited by CSI were obtained. Mean spectroscopy data and DTI values for each subject were correlated. Statistical analysis was performed by SPSS 13.0 software. Result： 1. The changes of FA values and ADC values in different part of human brains: Compared with pre-alcohol intake, mean FA values in frontal lobe and thalamus were increased (P0.01 respectively), and ADC reduced after alcohol intake (P0.01 respectively), and mean FA and ADC in low and high doses began to change at difference time point (2 h and 3 h respectively) after drinking. Mean FA values were higher (P0.05) and the ADC values were lower (P0.05) in frontal lobe in high doses group than that in low doses group. There were no significant differences in both of the the FA and A