四联药物治疗耐药HP感染临床疗效观察.docVIP

四联药物治疗耐药HP感染临床疗效观察 乔社卿1 单红艳2 殷景远2 (1鹤壁市第一人民医院河南鹤壁458000) (2黄河中心医院450003) 【摘要】目的：探寻高根治率的耐药HP感染的治疗方案，以减少和避免Hp 对抗生素的耐药。方法：收集我院2012.08?2013.08Hp —线方案治疗失败患者 78例,随机分为治疗组和对照组，疗程结朿4周后行活检组织快速尿素酶检测或 复查14C-尿素呼气试验。结果：治疗组根治率为87.50%，对照组根治率为60.53% , 治疗组疗效优于对照组，两组比较有显著性差异(Plt;0.05)。结论:应用埃索美拉 唑、左氧氟沙星、阿莫两林联合荆花胃康胶丸的补救方案能提高耐药Hp补救治 疗的根治率，可应用于耐药Hp初治失败后的治疗。 【关键词】幽门螺旋杆菌埃索美拉唑左氧氟沙星荆花胃康胶丸补救 方案 【中图分类号】R969.4 【文献标识码】A 【文章编号】1672-5085 (2014) 21-0149-02 Clinical observation of quadruple therapy of Hp with drug resistance QIAO She qingl YIN Jing yuan2 (l.Hebi First Peoplersquo;s Hospital 458000, Hebi Henan 2. Yellow River Central Hospital ) 【Abstract】 Objective: To explore a high radical treatment rate of Helicobacter pylori (Hp) with drug resistance so as to decrease and avoid Hp resistance to antibiotics. Methods: In our hospital we collected 78 patients which failed to use lst-line Hp treatment protocol from 08/2012-08/2013 and divided them into two groups by random: Treatment group and Control group. Rapid urease test (RUT) orl4C-urea breath test (14C-UBT ) were used to analyze the Hp radical treatment rate after 4 weeks of the treatment. Result:The Hp radical treatment rate of Treatment Group was higher than that of Control Group (87.5% vs 60.53%). There were significant difference between two groups (plt;0.05). Conclusion: The remedial fourfold therapy of Esomeprazole, Levofloxacin, Amoxicillin and Jinghuaweikang capsules could increase the radical treatment rate of Hp with drug resistance. This kind of therapy could be used to cure the patients with drug resistance Hp after the failure of lst-line therapy of Hp eradication. 【Keywords】 Helicobacter pylori Esomeprazole Llevofloxacin Jinghuaweikang capsules Remedial therayp 幽门嫁杆菌(helicobacter pylori,Hp)感染是最常见的慢性感染之一［1］，其相 关的胃十二指肠疾病如慢性活动性胃炎、消化性溃疡、MALT淋巴瘤、胃癌等疾 病严重影响人们的身体健康，但近年来药物根除Hp的成功率明显下降,Hp耐 药问题越来越突出［2】，我们在临床上使用埃索美拉唑、左氧氟沙星、阿莫西林 和荆花胃康胶丸联合的补救治疗方案，取得了较好的疗效。现介绍如下。 资料与方法 1.1 一般资料选择我院2012.08?2013.08经过正规一线方案根除Hp失败 的病例作为研究对象，所有病例均要求在一个月内经胃镜下活检组织快速尿