多奈哌齐联合尼莫地平治疗血管性痴呆的临床观察.docxVIP

多奈哌齐联合尼莫地平治疗血管性痴呆的临床观察 张延霞1金正贤2（通讯作者） 王利群1苏玉文1 （1解放军第88医院老年病科 山东泰安 271000） （2泰山医学院病理牛理教研室 山东泰安 271000） 【摘要】目的 通过观察多奈哌齐联合尼莫地平片治疗VD的疗效和治疗前 后MMSE、ADL评分的变化，了解其临床应用的可行性。方法 选择2010.6? 2013.11我科收治的脑梗死患者96例，对患者进行MMSE量表测评，依据得分 情况分为对照组（C组）与血管性痴呆组（VD组），其中VD组再分为多奈哌齐 联合尼莫地平治疗组（即联合治疗组）和单纯加服尼莫地平治疗组（尼莫地平组）， 其中联合治疗组男24例，女8例，平均78.8岁；尼莫地平组男23例，女9例，平 均77.5岁；对照组男21例八女11例，平均77.3岁，三组均给予相同的活血化瘀 药物等常规治疗及对症处理，联合治疗组在此基础上给予口服多奈哌齐及尼莫地 平，尼莫地平组在此基础上给予口服尼莫地平,8W 12W后行MMSE、ADL评 分及计算有效率。结果 8W、12W后，三组患者的MMSE评分、ADL评分均 升高，其中，联合治疗组8W.12W后评分均高于对照组和尼莫地平组（Plt;0.01）, 尼莫地平组12W后评分高于对照组（Plt;0.05）o临床疗效比较，联合治疗组8W、 12W后总有效率明显高于对照组与尼莫地平组（Plt;0.01）;尼莫地平组12W后 总有效率明显高于对照组（Plt;0.05）o结论多奈哌齐联合尼莫地平治疗血管 性痴呆疗效显著，无明显不良反应，临床中值得推广。 【关键词】多奈哌齐 尼莫地平 血管性痴呆 临床观察 【中图分类号】R453 【文献标识码】A 【文章编号】2095-1752 （2014） 04-0031-02 Clinical observation on the effect of donepezil and nimodipine in the treatment of vascular dementiaZHANG Yan-xia,SU Yu-wen,WANG Li-qun,SONG of vascular dementia Yu-min department of Cadre,the 88th Hospital of PLA,Tairsquo;an,271000,China [Abstract] Objective The clinical curative effect observation and treatment of donepezil and nimodipine in the treatment of vascular dementia and changes of MMSE, ADL scale, to understand the feasibility of clinical application. Methods Choose 2010.6 to 2013.11 in our hospital from 62 cases of cerebral infarction patients, patients with the MMSE scale, based on scores were divided into control group (group C) and vascular dementia group (VD group), VD group was further divided into donepezil and nimodipine treatment group (i.e. combined treatment group) and simple oral nimodipine in treatment group (nimodipine group), the combined treatment group male 24 cases, female 8 cases, average 78.8 years old; nimodipine group male 23 cases, female 9 cases, average 77.5 years old; the control group male 21 cases, female 11 cases, average 74.3 years old, The three groups were given intravenous drip of Huoxue Huayu drugs and other conventional treatment and symptomatic treatment, the treatment gro