尿激酶溶栓治疗脑血栓56例临床观察.docxVIP

尿激酶溶栓治疗脑血栓56例临床观察 赵宗友陈金金杨艳陈影刘守山(安徽省阜南县人民医院神经内科安徽 阜南 236300) 【摘要】 目的 探讨尿激酶溶栓治疗脑血栓的临床效果。方法 选择56例脑 血栓患者，随机分为观察组和对照组，观察组用尿激酶溶栓治疗，对照组给予常 规治疗，比较两组临床疗效和神经功能缺损情况。结果治疗前两组神经功能缺 损评分并无统计学差异(Pgt；0.05),观察组在治疗6 h、治疗7d、治疗「个月 后欧洲卒中量表评分分别与对照组同期评分相比，差异有统计学意义(Plt;0.05)。 观察组总有效率为93%,对照组总有效率为71%,两组临床疗效比较差异有统 计学意义(Plt;0.05)o结论 尿激酶溶栓治疗脑血栓效果显著，改善患者神经功 能缺损，值得临床推荐。 【关键词】尿激酶脑血栓溶栓疗效 【中图分类号】R743.30 【文献标识码】A 【文章编号】2095-1752 (2013) 11-0123-02 Clinical effect of urokinase thrombolytic treatment of 56 patients with cerebral thrombosis ZHAO Zong-you,CHEN Jin-jin,YANG Yan, et al. (Department of Neurology,Peoples Hospital of Fu nan County,Fu nan 236300,China) [Abstract] Objective To explore the clinical effect of urokinase thrombolytie treatment of cerebral thrombosis? Methods Total 56 cases with cerebral thrombosis were randomly divided into the treatment group and the control group.The treatment group was treated with urokinase,the control group was treated with conventional treatment,the effect and neurologie impairment were compared? Results the neurologie impairment in the treatment group were not statistically different from those in the normal control group(Pgt;0.05) before treatment.but,the neurologie impairment in the treatment group were stat:istically d iff ere nt from those in the n ormal control group(Plt;0.05)after treatme nt.The total effective rate of the treatme nt group was 93%,the control group was 71%,a nd the differenee was statistical significant (Plt;0.05). Conclusion It has good effect to treat cerebral thrombosisby urokinase thrombolysis,it also Can improve neurologie impairment and should he widely used in clinic. [Key words] Urokinase Cerebral thrombosis Thrombolysis Effect 脑血栓形成(cerebral thrombosis, CT)是脑梗死中最常见的类型，指脑动 脉主干或其皮质支动脉粥样硬化及各类动脉炎等病变，导致血管的管腔狭窄和闭 塞，进而发生血栓形成，造成脑局部供血区血流中断，发生脑组织缺血、缺氧, 软化坏死。患者常有偏瘫、感觉障碍及失语等相应的神经系统症状和体征[1]。 溶栓治疗是其主要的治疗方法，通过溶栓治疗可以使闭塞的脑血管再通，重新供 血，抑制缺血的脑组织发生坏死。尿激酶是肾小球上皮细胞所产生的种特殊蛋 白分解酶，无抗原性，能使纤溶酶原激活为纤溶酶，致使纤维蛋白原、纤维蛋白 凝块以及前凝血因子V或VDI降解而溶解血栓⑵。我科采用尿激酶溶栓治疗脑血 栓，取得较为满