肿瘤学课件 呼吸系统肿瘤.pptVIP

Tumors of the Respiratory System呼吸系统肿瘤 Cancer of the Nasal Planum 鼻面癌 Rare in the dog, fairly common in the cat 犬少见，猫常见 The development of SCC- correlated to UV exposure, it is seen in older, lightly pigmented cats. SCC- most common:鳞状(上皮)细胞癌发展于紫外线暴露有关，主要在老年，有肤色浅的猫。鳞状细胞癌最常见： Carcinoma in situ, superficial SCC, or deeply infiltrative SCC 原位癌，表面鳞状细胞癌，或深层浸润性鳞状细胞癌 Other tumors at this site: 此区域中的其他肿瘤 Lymphoma, fibrosarcoma, hemangiosarcoma, melanoma, mast cell tumor, fibroma 淋巴瘤，纤维肉瘤，血管肉瘤，黑素瘤，肥大细胞瘤，纤维瘤 Cancer of the Nasal Planum 鼻面癌 History- 病史 SCC- usually a long history ( months to years) 鳞状细胞癌－通常有较长历史（成月上年） Stages- 阶段 Crusting and erythema 结壳和红斑 Superficial erosions and ulcers 表面腐蚀和溃疡 Deeply invasive and erosive lesions 深部侵入和腐蚀损伤 Associated eyelid, periauricular skin and ear pinna lesions may also be seen 眼睑多见，耳廓周围的皮肤和耳翼损伤可见 Cancer of the Nasal Planum 鼻面癌 Diagnosis 诊断 Biopsy! 活检 Therapy 疗法 Prevention- limit sun exposure! 预防－限制阳光照射 2 categories- 2种种类 Superficial minimally invasive disease 表面轻微侵入 Can be managed effectively- surgery, intralesional chemo, radiation…能被有效控制－－手术，真皮内化疗，放疗 2. Deeply infiltrating disease 深部浸润 Resistant to treatment (RT), Nosectomy 治疗抵抗，鼻切除 Nasal Tumors 鼻肿瘤 Speculated- 推测 dolichcephalic breeds or dogs living in urban environments- higher risk 长头品种或生活在城市内环境－高危 Older dogs, medium to large breeds 老年，中、大型犬 Less common in the cat 猫少见 Histology- 组织学 2/3- carcinomas 2/3－癌 Adenocarcinoma, SCC, undifferentiated 腺癌，鳞细胞癌，未分化 Sarcomas- 肉瘤 Fibrosarcoma, chondrosarcoma, osteosarcoma, undifferentiated sarcoma 纤维肉瘤，软骨肉瘤，骨肉瘤，未分化肉瘤 Nasal Tumors 鼻肿瘤 Rare- 少见 lymphoma (catdog) 淋巴癌（猫狗） TVT可传染性性病瘤 Polyps, fibromas 息肉，纤维瘤 Characterized by local invasion 局部入侵为特征 Met rate- 转移速率 low at the time of diagnosis 诊断时很少 at necropsy- 50% 验尸时-50％ Sites- lungs and lymph nodes 位置－肺部和淋巴结 Nasal Tumors 鼻肿瘤 Signs- 症状 Older animals with an intermittent and progressive history of initially unilateral epistaxis and/or mucopurulent discharge 有间断性和前进性的单侧鼻衄和/或脓性鼻液病史的老年犬 Ave