腹腔镜袖状胃切除手术治疗肥胖合并2型糖尿病患者的效果及对其胃肠激素水平的影响.docxVIP

PAGE PAGE 1 腹腔镜袖状胃切除手术治疗肥胖合并2型糖尿病患者的效果及对其胃肠激素水平的影响 　　 　　 徐锋 张启民 周心奇 　　 　　 　　[摘要]目的 研究经腹腔镜袖状胃切除手术（LSG）治疗肥胖合并2型糖尿病患者的效果及对其胃肠激素水平的影响。方法 选取2021年1月～2021年1月我院收治的88例肥胖合并2型糖尿病患者作为研究对象，将患者按照随机数字表法分为对照组和LSG组，每组各44例。对照组患者给予常规降糖药物及对症治疗，观察组在对照组的基础上采用LSG治疗。比较两组患者的体重指数（BMI）、血清糖化血红蛋白（HbA1c）、胰岛素、胃泌素、胰高血糖素样多肽-1（GLP-1）和肠抑胃肽（GIP）。结果 治疗后，LSG组患者的BMI及HbA1c水平低于对照组，差异有统计学意义（P0.05）;LSG组患者的胰岛素及胃泌素水平低于对照组，GLP-1水平高于对照组，差异有统计学意义（P0.05）;两组患者治疗后的GIP水平比较，差异无统计学意义（P0.05）。结论 LSG治疗肥胖合并2型糖尿病患者的效果显著，可以明显改善其胃肠激素水平，值得在临床推广应用。 　　[关键词]袖状胃切除手术;肥胖;2型糖尿病;胃肠激素 　　[Abstract] Objective To investigate the effect of laparoscopic sleeve gastrectomy （LSG） in the treatment of obesity complicated with type 2 diabetes and its effect on gastrointestinal hormone levels. Methods A total of 88 patients with obesity and type 2 diabetes treated in our hospital from January 2021 to January 2021 were selected as subjects， they were divided into control group and LSG group according to random number table method， with 44 cases in each group.Patients in the control group were given conventional hypoglycemic drugs and symptomatic treatment. The patients in the observation group were treated with LSG on the basis of the control group. The body mass index （BMI）， serum glycosylated hemoglobin （HbA1c）， insulin， glucagon-like polypeptide-1 （GLP-1）， intestinal inhibitory peptide （GIP）， and gastrin were compared between the two groups. Results After treatment， the BMI and HbA1c levels in the LSG group were lower than those in the control group， the differences were statistically significant （P0.05）. The insulin and gastrin levels in the LSG group were lower than those in the control group， and GLP-1 level was higher than that in the control group， the differences were statistically significant （P0.05）. There was no significant difference in GIP level between the two groups after treatment （P0.05）. Conclusion LSG is effective in the treatment of obesity complicated with type 2 diabetes， and significantly improves its gastrointesti