遗传与环境因素对双生姊妹性激素影响.docVIP

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遗传与环境因素对双生姊妹性激素影响.doc

遗传与环境因素对双生姊妹性激素影响 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1:遗传与环境因素对双生姊妹性激素影响 1 1 对象与方法 2 2 结果 3 22 青春期女性双生子血清E2,T浓度遗传环境效应分析 3 3 讨论 4 文2:宗族因素对村民自治的影响 4 一、宗族因素对村民自治的积极影响 5 1.有利于农村社会的稳定,给村民自治营造良好的社会环境 5 2.有利于对干部和政府权力的制约,维护村民群众的自治权 6 3.有利于村民道德水平的提高,为村民自治奠定思想基础 6 二、宗族势力对村民自治的危害 7 2.宗族势力参与村干部竞争,影响村干部的治村行为 8 三、结语 10 参考文摘引言: 10 原创性声明(模板) 11 文章致谢(模板) 11 正文 遗传与环境因素对双生姊妹性激素影响 文1:遗传与环境因素对双生姊妹性激素影响 Influence of genetic and environmental facto on serum estradiol and testosterone of twin girls Abstract: Objective To explore the change of serum estradiol (E2) and testosterone (T) concentratio throughout the puberty of girls and estimate the effects of genetic and environmental facto on serum E2 and T The study population coisted of 180 pai of twin girls aged 6 to 18 of pai monozygotic twi(MZ) and 48 pai dizygotic twi(DZ),who were all from Qingdao city of Shandong measurement and pubertal development stage were determined by Tanner serum E2 and T contents were assayed by Radioimmumo assay(RIA).Results Serum E2 and T concentratio increased from Tanner I to Ⅳ and decreased and T concentratio had substantial genetic variation,with additive genetic facto accounting for 40% and 47% of the total phenotypic variation, heritabilities of E2 and T in post-menarche girls were greater than those of non-menarche Serum E2 and T concentratio of pubertal girls were influenced both by the genetic and environmental facto,and genetic influence on E2 was significant after menarche occurred. Key words: girls;twin;heritability;puberty 青春期的内分泌变化是一系列表型变化的生物学基础,遗传与环境因素对青春期发育的效应可能通过其对青春期内分泌激素的作用实现。遗传因素对女性青春期发育的作用随青春期进展逐渐表达,环境因素可能不同程度地影响遗传基因在时间顺序上的表达。本文利用双生子研究,探讨遗传与环境因素对女性青春期前后血清性激素的相对效应。 1 对象与方法 11 对象 来自2002年12月2003年8月山东省青岛地区双生子登记系统,青春期同性别女性双生子180对,年龄6~18岁,其中同卵双生子(MZ)132对,异卵双生子(DZ)48对。检查性征发育,按照Tanner标准进行青春发育分期。询问有无月经来潮及月经初潮时间。并按乳房发育和月经初潮将研究对象分为乳房未发育组、乳房发育未来潮组和已潮组,分组估算遗传度。 12 血样采集与卵型鉴定 于上午8:00~9:00抽取空腹静脉血(同一对双生子采血时间一致),3000min离心10min,将分离的血清和血凝块分装密封后-40℃冰箱保

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