《Mechanisms of Real-Time, Proximal Sample Processing during Ambient Ionization Mass Spectrometry》.ppt

Literature Reports Yang Ping 2015.11 Faculty of Biology, Chemistry and Material Science, East China Institute of Technology Mechanisms of Real-Time, Proximal Sample Processing during Ambient Ionization Mass Spectrometry Authors： Andre R. Venter,* ,? Kevin A. Douglass, ? Jacob T. Shelley, ? Gregg Hasman, Jr., ? and Elahe Honarvar ? ? Department of Chemistry, Western Michigan University, Kalamazoo, Michigan 49008-5413, United States ? Department of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States Published in Analytical-Chemistry The preface 1. Ambient ionization methods are frequently said to require “no sample preparation”. 2. Advantages to the real-time sample processing of the ambient methods. 3. What is the differences between a purely ambient method and direct analysis methods？ The preface Liquid extraction Spray Desorption: 1.The sample processing takes place in four steps. 2.Every spray desorption method begins with the generation of a stable solvent spray. Primary spray: 1.The main factor affecting the initial droplet size is the spray solvent composition. 2.The main factor affecting the initial droplet velocity is the sheath gas exit velocity. Extraction: 1. liquid layer is formed when the surface is first bombarded. 2.The formation of this liquid layer is important for stable and reproducible analyses. Liquid extraction Spray Desorption: Desorption： Desorption is the process whereby analyte is transferred from the surface, carried away in secondary droplets. Ionization： The generation of charged secondary droplets during desorption ostensibly leads to an electrospray-like charging process, where small molecules become charged. Liquid extraction Liquid Microjunction Methods: 1.Three techniques have been reported that use a liquid microjuction for extraction :LMJ-SSP, nano-DESI, and LESA. 2. If the inner capillary is retract