Effects of atorvastatin on acute myocardial infarction myocardial expression of MPO concentration and TIMP-2-MMP-9 and its protective effect on cardiac function.docVIP

 PAGE \* MERGEFORMAT 20 Effects of atorvastatin on acute myocardial infarction myocardial expression of MPO concentration and TIMP-2/MMP-9 and its protective effect on cardiac function Of: Yu-Jie Li Kwong Chung Dong Festival Cai Anping Jiang Zhi Jian Rao Shaoqi Huang Yuli Gao Song Yuanbin Mak Wai-yee [Abstract] [Objective] atorvastatin on acute myocardial infarction myocardial myeloperoxidase (MPO) concentrations, tissue inhibitor of matrix metalloproteinase -2 / matrix metalloproteinase -9 (TIMP-2/MMP-9 ) expression and its protective effect on cardiac function. [Method] 40 male SD rats ligating the left coronary artery in acute myocardial infarction, survival, 35 were randomly divided into two groups. sham operation group 10. after 1 day of atorvastatin orally given (1 mg / kg / d, 17 rats), control group received normal saline (18) .14 d, the rats in each group the concentration of myocardial tissue MPO, collagen fiber content myocardial infarct size, TIMP-2/MMP-9 expression and heart function. [Results] control group, the concentration of myocardial myeloperoxidase, collagen fiber content, myocardial infarct size was significantly higher than that of atorvastatin treatment group (P lt;0.05), while the TIMP-2/MMP-9 ratio and cardiac function than atorvastatin group (P lt;0.05). [Conclusion] atorvastatin can improve cardiac remodeling in rats with acute myocardial infarction and cardiac function, primarily by reducing leukocyte infiltration, reduced concentration and regulation TIMP-2/MMP-9 MPO expression, thereby reducing myocardial infarct size and collagen fiber content. [Keywords:] Acute myocardial infarction; myeloperoxidase; cardiac remodeling; heart function Abstract: [Objective] To investigate the effects of atorvastatin on concentration of MPO and expression of TIMP-2/MMP-9 in left ventricle, and preservation of heart function after myocardial infarction in rat. [Methods] Acute myocardial infarction was performed by ligating left coronary