Effects of atorvastatin on acute myocardial infarction myocardial expression of MPO concentration and TIMP-2-MMP-9 and its protective effect on cardiac function.docVIP
- 1、本文档共20页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Effects of atorvastatin on acute myocardial infarction myocardial expression of MPO concentration and TIMP-2-MMP-9 and its protective effect on cardiac function
PAGE \* MERGEFORMAT 20
Effects of atorvastatin on acute myocardial infarction myocardial expression of MPO concentration and TIMP-2/MMP-9 and its protective effect on cardiac function
Of: Yu-Jie Li Kwong Chung Dong Festival Cai Anping Jiang Zhi Jian Rao Shaoqi Huang Yuli Gao Song Yuanbin Mak Wai-yee
[Abstract] [Objective] atorvastatin on acute myocardial infarction myocardial myeloperoxidase (MPO) concentrations, tissue inhibitor of matrix metalloproteinase -2 / matrix metalloproteinase -9 (TIMP-2/MMP-9 ) expression and its protective effect on cardiac function. [Method] 40 male SD rats ligating the left coronary artery in acute myocardial infarction, survival, 35 were randomly divided into two groups. sham operation group 10. after 1 day of atorvastatin orally given (1 mg / kg / d, 17 rats), control group received normal saline (18) .14 d, the rats in each group the concentration of myocardial tissue MPO, collagen fiber content myocardial infarct size, TIMP-2/MMP-9 expression and heart function. [Results] control group, the concentration of myocardial myeloperoxidase, collagen fiber content, myocardial infarct size was significantly higher than that of atorvastatin treatment group (P lt;0.05), while the TIMP-2/MMP-9 ratio and cardiac function than atorvastatin group (P lt;0.05). [Conclusion] atorvastatin can improve cardiac remodeling in rats with acute myocardial infarction and cardiac function, primarily by reducing leukocyte infiltration, reduced concentration and regulation TIMP-2/MMP-9 MPO expression, thereby reducing myocardial infarct size and collagen fiber content.
[Keywords:] Acute myocardial infarction; myeloperoxidase; cardiac remodeling; heart function
Abstract: [Objective] To investigate the effects of atorvastatin on concentration of MPO and expression of TIMP-2/MMP-9 in left ventricle, and preservation of heart function after myocardial infarction in rat. [Methods] Acute myocardial infarction was performed by ligating left coronary
您可能关注的文档
- Effect of atorvastatin on inflammatory mediators in patients with chronic heart failure and cardiac function.doc
- Effect of atrial fibrillation Factors.doc
- EEG diagnosis of atypical aged 31 cases of viral encephalitis.doc
- EEG diagnosis of viral encephalitis in the application of old.doc
- Effect of captopril on hypoxia reoxygenation in ventricular myocytes ATP-sensitive potassium channel content.doc
- Effect of allicin on human gastric cancer SGC7901 cell growth.doc
- Effect of carvedilol on heart disease in patients with extended left ventricular function caused by inflammatory factors in the impact of changes.doc
- Effect of carvedilol on doxorubicin induced cardiomyopathy the impact of oxidative stress in rats.doc
- Effect of carvedilol intervention in patients with chronic heart failure in cardiac function and vascular endothelial function.doc
- Effect of carvedilol on the combined treatment of Shen Mai injection completely refractory congestive heart failure in 1 case and reverse left ventricular remodeling_0.doc
- Effects of berberine on human nasopharyngeal carcinoma CNE2 content of intracellular calcium.doc
- Effects of dexamethasone on LPS-induced acute lung injury in Rats.doc
- Effects of berberine on mice gastric ulcer effect of vasoactive substances in.doc
- Effects of atorvastatin on essential hypertension with the intervention of paroxysmal atrial fibrillation.doc
- Effects of estrogen on bone ApoE knockout mice and RANKL OPG effects.doc
- Effects of fertilization on levels of mineral elements and Fritillaria Yield and Its Correlation Analysis.doc
- Effects of estrogen on ovariectomized hyperlipidemic C57BL - 6 mice the expression of ZFP580 mRNA.doc
- Effects of acupuncture on depressive behavior in rats and Neuroendocrine.doc
- Effects of berberine on diabetic rat aorta endothelial injury.doc
- Effects of ginsenosides on heat-damaged rats with glucocorticoid receptors in different organs of.doc
最近下载
- AB-罗克韦尔PowerFlex755变频器操作说明.pdf
- 2024-2025学年初中信息技术(信息科技)青岛版(2024)第一册教学设计合集.docx
- ANSI-ESD S20.20-2021电气和电子零件装置和设备的静电保护.pdf VIP
- 养鸡创业计划书3篇农村养鸡创业计划书范文.pdf VIP
- QGDW11190-2014农网高过载能力配电变压器技术导则.pdf VIP
- 全国市政排水管道工程施工质量通病的防治.pptx VIP
- 财务报表词汇-中英对照.docx VIP
- 2025至2030中国冬虫夏草行业市场发展分析及趋势前景与行业项目调研及市场前景预测评估报告.docx VIP
- 治具设计完整版.pptx VIP
- 广西壮族自治区南宁市2025年八年级下学期期末数学模拟试题九套含答案.pptx VIP
文档评论(0)