Fluoride on the rat thyroid gland morphology thyroid peroxidase activity and serum thyroid hormone.docVIP

 PAGE \* MERGEFORMAT 11 Fluoride on the rat thyroid gland morphology thyroid peroxidase activity and serum thyroid hormone [Abstract] Objective To observe the morphology of fluoride on rat thyroid, thyroid peroxidase (TPO) activity and serum thyroid hormones. Methods weaning 1 month old SD rats were randomly divided into control group, low dose group, the fluoride group , fluoride groups, respectively, with different fluoride concentrations of drinking water, were sacrificed after feeding for 6 months. removal of the thyroid gland, thyroid gland morphology were observed in the optical changes in the structure; improved method for the determination of guaiacol TPO activity; by radioimmunoassay serum thyroid hormone levels. The results of some high fluoride group significantly increased follicular, follicular cavity filled with stain collagen. low fluoride group, the fluoride group, each group with the high fluoride group fluoride dose, the thyroid had oxidase (TPO) activity was significantly decreased compared with the control group (P lt;0.05). fluoride group FT4 levels were significantly lower than (P lt;0.05), with statistical significance. Conclusion Long-term intake of excessive fluoride can cause changes of thyroid tissue, inhibition of TPO activity, resulting in decreased thyroid hormone synthesis, can be seen that fluoride can cause goiter, and lead to abnormal thyroid metabolism. [Keywords:] thyroid hormone; fluoride; thyroid peroxidase; rat Abstract: Objective To observe the effects of fluoride on thyroid morphology, thyroid peroxidase and serum thyroid hormones. Methods One-month ablactating SD rats were randomly divided into three groups: the control group, low-fluoride group, middle-fluoride group, high- fluoride group, fed with water containing different fluoride concentration by adding NaF respectively. Rats were sacrificed after being fed for six months. The morphology of thyroid was observed through light microscope. The TPO activity wa