HSP 70 and myocardial protection.docVIP

 PAGE \* MERGEFORMAT 24 HSP 70 and myocardial protection Heart transplantation for end-stage heart disease the only effective treatment, but the heart is different from other body tissues and organs for heart transplantation from a cut to get into the receptors in vivo ischemia, hypoxia a longer time, and it receptors in the implantation After the restore function as soon as possible, immediately carry blood from the body of the function of other organs to ensure life. Therefore, the donor heart myocardial protection extremely important. Now, with the improvement of clinical surgical technique for heart warm ischemia time can be controlled by the basic 6 ~ 10min, how to extend the donor heart cold ischemic time, strengthening myocardial protective effect, reducing myocardial ischemia-reperfusion injury, in order to calm the transport and surgery, and even the establishment of an organ bank, resource sharing, that is, become the heart transplant research focus, but also affect the heart transplant carried out extensive bottleneck problem. Heat shock proteins (HSP 70s) is currently the concern of stress proteins, which, as a ‘molecular chaperones’ participation in a variety of cell injury and repair of myocardial cells also have a protective effect. To improve myocardial HSP 70 content in ways there are two types: (1)-induced expression of endogenous HSP 70; (2) into exogenous HSP 70 gene. The implementation of myocardial protection in recent years, many studies focused on the mobilization of endogenous cardiac protection mechanisms in order to improve myocardial oxygen capacity of self-tolerance. In this paper, endogenous HSP 70 and myocardial protection based on the following overview of the progress. 1 HSP 70 Overview 1.1 HSP 70 of the classification and distribution of heat shock protein (heat shock protein, HSP) is a group of highly conserved peptide, exists in vivo. HSPs study is the observation of the fruit fly larvae in response to heat stress b