S100A4 and VEGFC expression and lymph node metastasis of gastric cancer.docVIP

 PAGE \* MERGEFORMAT 5 S100A4 and VEGFC expression and lymph node metastasis of gastric cancer [Abstract] Objective: To observe the S100A4 and vascular endothelial growth factor C (VEGF  C) in gastric tissue to analyze its relationship with tumor lymphatic metastasis as well as the correlation between the two. Methods: Immunohistochemical Detection of S100A4 and the VEGF  C in 76 cases of gastric cancer and 24 cases of adjacent normal tissues. Results: S100A4 and VEGF  C in gastric carcinoma The positive expression rate was significantly higher than that peritumoral normal tissue (P amp;lt;0.01). S100A4 expression and degree of tumor differentiation, TNM stage and lymph node metastasis (P amp;lt;0.01 or P amp;lt;0.05); VEGF  C expression and tumor depth of invasion, TNM stage and lymph node metastasis (P amp;lt;0.01 or P amp;lt;0.05). S100A4, and the expression of VEGF  C was positively correlated (rs = 0.334, P = 0.003), kappa coefficient of 0.298. Conclusion: S100A4 may be involved in lymphangiogenesis VEGF  C pathway, lymph node metastasis in gastric cancer to play an important role. [Keywords:] stomach tumor endothelial growth factor and lymph node metastasis of calcium-binding proteins 0 Introduction Gastric cancer is one of common malignant tumor in China, early lymph node metastasis can occur. A large number of studies have shown that whether there is lymph node metastasis is an important prognostic factor in patients with gastric cancer [1-3]. Vascular endothelial growth factor C (VEGF  C) is currently the found in primary lymphatic endothelial cells, regulatory factors, can induce solid tumors or in tumor lymphangiogenesis week, and is closely related to lymph node metastasis of malignant tumors [4-5]. S100A4 is a calcium-binding protein, a member of the S100 family, In recent years, found that S100A4 expression in a variety of malignant tumors, its expression and tumor stage and lymph node metastasis, was considered to be a tumor met