Association of Human Herpesvirus 6 and 8 in Relapsing Remitting Multiple Sclerosis Type during Exacerbation英文文献资料.docVIP

Neuroscience Medicine, 2010, 1, 33-37 33 doi:10.4236/nm.2010.11005 Published Online September 2010 (http://www.SciRP.org/journal/nm) Association of Human Herpesvirus 6 and 8 in Relapsing Remitting Multiple Sclerosis Type during Exacerbation Hassan Salama , Mohamed El-Khateeb , Rawya Bader , Mohamed Saleh , Enas Hamad 1 1 2 2 2 1 Department of Neurology, Mansoura University, ElJomhoria st Mansoura University, Mansoura, Egypt; Department of Microbiol- 2 ogy and Immunology; Mansoura University, Mansoura, Egypt. Email: hassansalama@ Received June 28 , 2010; revised August 3 , 2010; accepted August 10 , 2010. th rd th ABSTRACT Multiple Sclerosis (MS) is a chronic demyelinating disease of the CNS with assumed autoimmune etiology. Human herpes viruses have probable effects on relapsing-remitting MS pathogenesis presumably through molecular mimicry and/or bystander mechanisms. In this study we probed the possible contribution of the two herpes viruses, human herpesvirus 6 (HHV-6) and human herpesvirus 8 (HHV-8), in clinically definite multiple sclerosis (CDMS) pa- tients-relapsing remitting type (RRMS) during clinical exacerbations. All patients had no history of immune modulating or suppressing drugs intake in the last 6 months. The peripheral blood samples, from CDMS patients (n = 20) (13F/7M, age (y) = 30.3 ± 3.21) and other immune mediated neurological disorders (OIND) (11F/9M, age = 25.2 ± 12.1), (My- asthenia Gravis, Guillain Barré Syndrome, ischemic stroke in adolescent and young adult with no clear risk factors), as a control group, had been enrolled within 15 months (January-2007-- March -2008). We investigate