Association of Mitral Annulus Calcification with High-Sensitivity C-Reactive Protein, Which Is a Marker of Inflammation英文文献资料.docVIP

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Association of Mitral Annulus Calcification with High-Sensitivity C-Reactive Protein, Which Is a Marker of Inflammation英文文献资料.doc

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Association of Mitral Annulus Calcification with High-Sensitivity C-Reactive Protein, Which Is a Marker of Inflammation英文文献资料

HindawiPublishingCorporation MediatorsofIn?ammation Volume2012,ArticleID606207,6pages doi:10.1155/2012/606207 ResearchArticle AssociationofMitralAnnulusCalci?cationwithHigh-Sensitivity C-ReactiveProtein,WhichIsaMarkerofIn?ammation Ertu?grulKurto?glu, HasanKorkmaz, ErdalAkt¨urk, M¨ucahidY?lmaz, 1 1 2 1 YakupAltas?, andAhmetUc?kan 3 1 1 2 3 DepartmentofCardiology,Elaz?g?EducationandResearchHospital,23100Elaz? g?,Turkey DepartmentofCardiology,Ad?yamanUniversityFacultyofMedicine,02040Ad?yaman,Turkey DepartmentofCardiology,SevgiHospital,44040Malatya,Turkey CorrespondenceshouldbeaddressedtoErtu?grulKurto?glu,erkurtoglu@ Received20October2011;Revised11December2011;Accepted13December2011 AcademicEditor:AlexKleinjan Copyright?2012Ertu?grulKurto?gluetal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Objectives.Therearelimitedclinicaldatarevealingtherelationshipbetweenmitralannularcalci?cation(MAC)andsystemic in?ammation. The goal of the present study was to compare high-sensitivity C-reactive protein (hs-CRP) levels in patients withandwithoutMACandinvestigatetherelationshipbetweenMACandhs-CRP.Methods.OnehundredpatientswithMAC whounderwenttransthoracicechocardiography(TTE)and100age-matchedcontrolswithoutMACwhounderwentTTEwere includedinourstudy.Hs-CRPlevelswerecomparedbetweengroups.Results.Prevalenceoffemalegender,hypertension,and coronaryartery diseaseweresigni?cantlyhigherintheMACgroupthaninthecontrolgroup(64%versus45%, P = 0.007, 42%versus28%,P = 0.03and37%versus18%,P = 0.003,resp.).Onmultivariateanalysis,age,gender,andcoronaryartery diseaseweretheonlyindependentpredictorsofMAC.Thelevelsofhs-CRPwerehigherintheMACgroupthaninthecontrol group(2.02± 0.35versus1.43± 0.47mg/dl,P 0.001).Thisincreaseinhs-CRPlevelsintheMACgrouppersistedinpatients withouthypertension