Association of CYP2C19 genotype with type 2 diabetes英文文献资料.docVIP

Vol.2, No.10, 1184-1190 (2010) Health doi:10.4236/health.2010.210174 Association of CYP2C19 genotype with type 2 diabetes Carlos Hoyo-Vadillo *, Jaime Garcia-Mena , Adán Valladares , Caterina R. Venturelli , Niels 1 2 3 1 5 3 Wacher-Rodarte 4 , Jesús Kumate , Miguel Cruz 1 2 3 Department of Pharmacology, Cinvestav-IPN Zacatenco, México City, Mexico; *Corresponding Author: citocromo@cinvestav.mx Departamento de Genética y Biología Molecular, Cinvestav-IPN Zacatenco, México City, Mexico Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI del IMSS, México City, Mexico Unidad de Investigación Médica en Epidemiología, Hospital de Especialidades, Centro Médico Nacional Siglo XXI de IMSS, México City, Mexico Fundación IMSS, México City, Mexico 4 5 Received 4 July 2010; revised 13 July 2010; accepted 20 July 2010. ABSTRACT 1. INTRODUCTION Background: CYP2C19 is a major isoform of cytochrome P450 that metabolizes a number of commonly prescribed drugs such as omepraz- ole, diazepam, tolbutamide and propranolol. Its expression is regulated by the constitutive and- rostane receptor (CAR), involved in glucocorti- coids synthesis. Since a number of crosslinks have been described for CYPs and some horm- ones, an association of CYP2C19 with type 2 diabetes is likely. Methods: Two groups were studied, 352 diagnosed with type 2 diabetes patients and 342 healthy volunteers form Mexi- co City. Both groups were tested for CYP2C19*2 and *3 alleles. We carried out an allelic discri- mination using TaqMan assay for *2, and used FRET sensor and anchor probes for *3. Results: Ninety one percent of the subjects had the wild type allele, 9% have the *2 allele; no subject p