Association of MCP-1 -2518 AG Single Nucleotide Polymorphism with the Serum Level of CRP in Slovak Patients with Ischemic Heart Disease, Angina Pectoris, and Hypertension英文文献资料.docVIP

下载本文档

2
0
约2.44万字
约 7页
2017-05-10 发布于上海
举报
版权申诉

Association of MCP-1 -2518 AG Single Nucleotide Polymorphism with the Serum Level of CRP in Slovak Patients with Ischemic Heart Disease, Angina Pectoris, and Hypertension英文文献资料.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Association of MCP-1 -2518 AG Single Nucleotide Polymorphism with the Serum Level of CRP in Slovak Patients with Ischemic Heart Disease, Angina Pectoris, and Hypertension英文文献资料

HindawiPublishingCorporation MediatorsofIn?ammation Volume2009,ArticleID390951,6pages doi:10.1155/2009/390951 ClinicalStudy AssociationofMCP-1-2518A/GSingleNucleotidePolymorphism withtheSerumLevelofCRPinSlovakPatientswith IschemicHeartDisease,AnginaPectoris,andHypertension MariaBucova, 1 JanLietava, PeterPenz, FrantisekMrazek, JanaPetrkova, 2 3 4 5 andMartinPetrek 4 MarianBernadic, 6 1 2 3 4 InstituteofImmunology,FacultyofMedicine,ComeniusUniversity,81108Bratislava,Slovakia DepartmentofInternalMedicineII,FacultyofMedicine,ComeniusUniversity,81369Bratislava,Slovakia DepartmentofInternalMedicineI,FacultyofMedicine,ComeniusUniversity,81369Bratislava,Slovakia LaboratoryofImmunogenomics,DepartmentofImmunology,FacultyofMedicine,PalackyUniversity, 77900Olomouc,CzechRepublic 5 6 DepartmentofInternalMedicineI,FacultyHospital,77900Olomouc,CzechRepublic InstituteofPathologicalPhysiology,FacultyofMedicine,ComeniusUniversity,81108Bratislava,Slovakia CorrespondenceshouldbeaddressedtoMariaBucova,maria.bucova@ Received29May2009;Accepted29May2009 RecommendedbySunitKumarSingh Theaimofourworkwasto?ndifMCP-1-2518(A/G)singlenucleotidepolymorphism(SNP)in?uencessomehowtheserum concentrationsofhigh-sensitiveCRP(hsCRP)bothinpatientssu?eringfromischemicheartdisease(IHD),myocardialinfarction (MI),anginapectoris(AP),andhypertension(HT)andincontrolgroupofhealthysubjects.Totally,263patientswiththediagnosis ofIHD,outofthem89withMI,145withAP,205withHT,andalso67healthysubjectswereincludedinthestudy.First,we estimatedtheserumlevelsofhsCRP.WefoundthatpatientswithAPhadsigni?cantlyhigherserumlevelofhsCRPthanboth controlgroupofhealthysubjects(P = .043)andIHDpatientswithoutAP(P = .026).ThepresenceofthemutantGallele statisticallysigni?cantlycorrelatedwiththehigherserumlevelsofhsCRPinpatientswithIHD(P =.016),AP(P =.004),and HT(P=.013).Highercorrelationswerefoundinmen(AP:P=.019;HT:P=.047).InallcasesthehighestlevelsofhsCRPwere foundbothinpatient