Association of Inflammatory and Oxidative Stress Markers with Metabolic Syndrome in Asian Indians in India英文文献资料.docVIP

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Association of Inflammatory and Oxidative Stress Markers with Metabolic Syndrome in Asian Indians in India英文文献资料.doc

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Association of Inflammatory and Oxidative Stress Markers with Metabolic Syndrome in Asian Indians in India英文文献资料

SAGE-HindawiAccesstoResearch CardiologyResearchandPractice Volume2011,ArticleID295976,8pages doi:10.4061/2011/295976 ResearchArticle AssociationofIn?ammatoryandOxidativeStressMarkerswith MetabolicSyndromeinAsianIndiansinIndia VeenaS.Rao, RadhikaK.Nagaraj, SridharaHebbagodi, 1 2 2 NateshaB.Kadarinarasimhiah, 1andVijayV.Kakkar 1,2 1 TataProteomicsandCoagulationUnit,ThrombosisResearchInstitute,NarayanaHrudayalaya,258/ABommasandraIndustrialArea, AnekalTaluk,Bangalore560099,India 2 EmmanuelKayeBioinformaticsCentre,ThrombosisResearchInstitute,Bangalore560099,India CorrespondenceshouldbeaddressedtoVeenaS.Rao,veenasrao@.in Received30September2010;Revised29October2010;Accepted5November2010 AcademicEditor:ReiShibata Copyright?2011VeenaS.Raoetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Metabolicsyndrome(MetS)isaprimaryriskfactorforcardiovasculardiseaseandisassociatedwithaproin?ammatorystate. Here,weassessedthecontributionofin?ammatoryandoxidativestressmarkerstowardspredictionofMetS.Atotalof2316 individualswererecruitedinPhaseIoftheIndianAtherosclerosisResearchStudy(IARS).Modi?edATPIIIguidelineswereused forclassi?cationofsubjectswithMetS.Amongthein?ammatoryandoxidativestressmarkersstudied,levelsofhsCRP(P.0001), Neopterin(P=.036),andoxLDL(P.0001)weresigni?cantlyhigheramongsubjectswithMetS.Amongthemarkerswetested, oxLDLstoodoutasarobustpredictorofMetSintheIARSpopulation(OR4.95695%CI2.504–9.810;P .0001)followedby hsCRP(OR1.32495%CI1.070–1.638;P = .010).Inconclusion,oxLDLisacandidatepredictorforMetSintheAsianIndian population. 1.Introduction source of proin?ammatory cytokines [8], and it has been reportedthatenhancedsecretionofinterleukin6(IL-6)and tumornecrosisfactor(TNF-α)byadipocytesandmonocyte- derived macrophages leads to more insulin resistance and lipolysis of adipose tissue tri