Bronchoalveolar Activation of Coagulation and Inhibition of Fibrinolysis during Ventilator-Associated Lung Injury英文文献资料.docVIP

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Bronchoalveolar Activation of Coagulation and Inhibition of Fibrinolysis during Ventilator-Associated Lung Injury英文文献资料.doc

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Bronchoalveolar Activation of Coagulation and Inhibition of Fibrinolysis during Ventilator-Associated Lung Injury英文文献资料

HindawiPublishingCorporation CriticalCareResearchandPractice Volume2012,ArticleID961784,8pages doi:10.1155/2012/961784 ClinicalStudy BronchoalveolarActivationofCoagulationandInhibitionof FibrinolysisduringVentilator-AssociatedLungInjury M.J.Schultz, 1 R.M.Determann,1,2A.A.N.M.Royakkers,3 J.C.Korevaar, andM.M.Levi E.K.Wolthuis, 4 5 2 1 2 3 4 5 DepartmentofIntensiveCareMedicine,AcademicMedicalCenter,Meibergdreef9,Amsterdam,1105AZ,TheNetherlands DepartmentofInternalMedicine,AcademicMedicalCenter,Meibergdreef9,Amsterdam,1105AZ,TheNetherlands DepartmentofAnesthesiology,TergooiZiekenhuizen,Rijksstraatweg1,Blaricum,1261AN,TheNetherlands DepartmentofAnesthesiology,AcademicMedicalCenter,Meibergdreef9,Amsterdam,1105AZ,TheNetherlands DepartmentofBiostatisticsandEpidemiology,AcademicMedicalCenter,Meibergdreef9,Amsterdam,1105AZ,TheNetherlands CorrespondenceshouldbeaddressedtoR.M.Determann,r.m.determann@amc.uva.nl Received1April2011;Accepted12February2012 AcademicEditor:PeterJ.Papadakos Copyright?2012M.J.Schultzetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. BackgroundandObjective.Bronchoalveolarcoagulopathyisacharacteristicfeatureofpulmonaryin?ammation.Wecompared bronchoalveolarandsystemiclevelsofcoagulationinpatientswhodidandpatientswhodidnotdevelopventilator-associated lunginjury (VALI).Methods.Secondaryanalysisofarandomizedcontrolledtrialevaluatingthee?ectoflowertidalvolumes versusconventionaltidalvolumesinpatientswithoutacutelunginjuryoracuterespiratorydistresssyndromeattheonsetof mechanicalventilation.Results.TenpatientswithVALIand10randomcontrolpatientswithoutlunginjuryduringthecourseof mechanicalventilation,butallventilatedwithconventionaltidalvolumes,werecompared.PatientswhodevelopedVALIshowed bothbronchoalveolaractivationofcoagulation(increaseinthrombin–antithrombincomplexlevelsP0.001versusbaseline)and inhibitionof?brinolysis