Bronchiolitis Obliterans Organizing Pneumonia in Swine Associated with Porcine Circovirus Type 2 Infection英文文献资料.docVIP

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Bronchiolitis Obliterans Organizing Pneumonia in Swine Associated with Porcine Circovirus Type 2 Infection英文文献资料.doc

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Bronchiolitis Obliterans Organizing Pneumonia in Swine Associated with Porcine Circovirus Type 2 Infection英文文献资料

HindawiPublishingCorporation JournalofBiomedicineandBiotechnology Volume2011,ArticleID245728,9pages doi:10.1155/2011/245728 ResearchArticle BronchiolitisObliteransOrganizingPneumoniain SwineAssociatedwithPorcineCircovirusType2Infection Ching-ChangCheng,1,2Yen-FengLee,1,2Nai-NuLin,1,2Chieh-LiangWu,3 Kwong-ChungTung, 2 andYung-TsungChiu 1,4 1 DepartmentofEducationandResearch,TaichungVeteransGeneralHospital,160,Section3TaichungkangRoad, Taichung40705,Taiwan 2 3 4 DepartmentofVeterinaryMedicine,NationalChung-HsingUniversity,Taichung40227,Taiwan DivisionofCriticalCareandRespiratoryTherapy,TaichungVeteransGeneralHospital,Taichung40705,Taiwan DepartmentofAnimalScience,NationalChung-HsingUniversity,Taichung40227,Taiwan CorrespondenceshouldbeaddressedtoYung-TsungChiu,ytchiu@vghtc.gov.tw Received24June2010;Revised11August2010;Accepted7September2010 AcademicEditor:MonicaFedele Copyright?2011Ching-ChangChengetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Bronchiolitisobliteransorganizingpneumonia(BOOP)isachronicrespiratorydisease.AlthoughthepathogenesisofBOOPis stillincompletelyunderstood,BOOPisresponsivetosteroidsandhasagoodprognosis.Inour?vepigswithchronicpostweaning multisystemicwastingsyndrome(PMWS),typicalBOOPlesionswererevealed.All?veporcinelungsshowedtypicalintraluminal plugs,andporcinecircovirustype2(PCV2)wasidenti?ed.Theyalsoexhibitedsimilarpathologic?ndingssuchasproliferation oftypeIIpneumocytesandmyo?broblasts(MFBs),extracellularcollagenmatrix(ECM)deposition,andfragmentationofelastic ?bers.MFBsmigrationcorrelativemolecules,forinstance,gelatinaseA,Bandosteopontin,appearedstronglyintheprogressing marginalareaofpolypoidintraluminalplugsof?broticlesion.ThesemoleculescolocalizedwiththeactiveMFBs.Bothgelatinase activityandintercellularlevelofactiveMFBsweresigni?cantlyincreased(P.05).Porcinechronicbronchopneumonialeadsto BOOPandi