加替沙星、左氧氟沙星序贯治疗下呼吸道感染的药物经济学评价.pdfVIP

· 药物经济学· 加替沙星、左氧氟沙星序贯治疗下呼吸道感染的 药物经济学评价 孟 雪 ，竺顺斌，张利诚，苗佩宏 (武警浙江省总队医院，嘉 ／x市 314000) 中图分类号 R978．1 文献标识码 B 文章编号 1672—2124(2008)02—0133—04 摘 要 目的：评价加替沙星静脉滴注和加替沙星静脉滴注与左氧氟沙星口服序贯治疗下呼吸道感染的成本一效果，为，临床制 定合理用药方案提供参考 。方法：将256例下呼吸道感染患者随机分为2组，其中对照组应用加替沙星注射液400mg静脉滴注， qd；序贯组用加替沙星注射液400mg静脉滴注qd，3d后改为口服左氧氟沙星片400mg，qd，疗程均为7～14d，观察两组的I临床疗效， 并进行成本一效果分析。结果：2组在，临床疗效、细菌学清除率及不良反应发生率方面差异无统计学意义(P0．05)，但对照组的 费用却显著高于序贯治疗组(P0．05)。结论：加替沙星、左氧氟沙星序贯治疗下呼吸道感染具有与单用加替沙星静脉滴注相似 的，临床疗效，但比单用更具经济学意义，是治疗下呼吸道感染的经济合理方案。 关键词 加替沙星；左氧氟沙星；下呼吸道感染；序贯治疗；药物经济学 Sequential Therapy of Gatifloxacin and Levofloxacin for Lower Respiratory Tract Infections： Pharmacoeconomic Analysis MENG Xue ，ZHU Shun—bin，ZHANG Li—cheng，MIAO Pei—hong (Zhejiang Provincial Corps Hospital of Chinese People’S Armed Police Forces，Jiaxing 3 14000，China) ABSTRACT OBJECTIVE：To evaluate the pharmacoeconomic efficacy of sequential therapy of gatifloxacin and levofloxaein in the treatment of lower respiratory tract infections(LRTI)for referenees of rational drug use in the clinical practice．METHODS：A total of 256 inpatients with LRT1 were randomized to two groups：the control group was assigned to receive gatifloxacin injection 400mg by iv gtt q．d，while the treatment group(sequential group)to receive gatifloxacin injection 400mg q．d for 3 days followed by oral levofloxacin 400mg q．d．The course of treatment was 7～14 days in both group．Clinical efficacy in two groups was observed and cost—effectiveness analysis was made after the treatment． RESULTS：There were no significant difference between two groups in effective rate，germ—clearance rates and incidence of ADRs(P0．05)，but the cost in the control group was significantly higher than in sequential group(P0．05)． CONCLUSION：The sequential therapy of gatifloxacin and levofloxacin is equivalent to gatifloxacin alone in clinical efficacy， but is superior to the latter one in cost—effectiveness，which turned out to be an economic and reasonable therapy for low